Sinemet and Skelaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Skelaxin (metaxalone). Common drug interactions include breast cancer among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Skelaxin. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

On Jul, 07, 2026

55 people who take Sinemet and Skelaxin together, and have interactions are studied.

What are the common drug interactions of Sinemet and Skelaxin, by gender? *:

female:

Breast cancer
Confusional state
Dyspnoea (difficult or laboured respiration)
Metastases to central nervous system (cancer spreads to central nervous system)
Muscle twitching
Osteonecrosis of jaw (death of bone of jaw)
Abdominal pain upper
Arthralgia (joint pain)
Balance disorder
Brain mass

male:

Depression
Leukaemia (blood or bone marrow cancer)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Constipation
Dehydration (dryness resulting from the removal of water)
Drug effect delayed
Dysphasia (language disorder marked by deficiency in the generation of speech)
Dysstasia (difficulty in standing)
Fear

What are the common drug interactions of Sinemet and Skelaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Glaucoma (increased fluid pressure in the eye with vision loss)
Hypertension (high blood pressure)
Neuropathy peripheral (surface nerve damage)
Purpura senile (skin condition in which areas of the skin develop a purplish or reddish-brown appearance due to bleeding of small blood vessels underneath)
Renal failure (kidney dysfunction)
Resorption bone increased

40-49:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone disorder
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chest discomfort
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Cough
Deformity (disfigurement)
Dental caries

50-59:

Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Incontinence (lack of moderation or self-control)
Loss of consciousness
Muscle tightness
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)

60+:

Fall
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cheilitis (infection of lips)
Contusion (a type of hematoma of tissue in which capillaries)
Dental caries
Dizziness
Drug effect decreased
Dyspnoea exertional (breathlessness or shortness of breath)
Facial pain
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Pain: 17 people, 30.91%
Multiple Myeloma (cancer of the plasma cells): 15 people, 27.27%
Depression: 14 people, 25.45%
Neoplasm Malignant (cancer tumour): 13 people, 23.64%
Pain In Jaw: 12 people, 21.82%
Muscle Spasms (muscle contraction): 5 people, 9.09%
Impetigo (contagious skin infection): 4 people, 7.27%
Belching (release of gas from the digestive tract): 4 people, 7.27%
Stress And Anxiety: 3 people, 5.45%
Oedema Peripheral (superficial swelling): 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

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