Singulair and Polytrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Singulair (montelukast sodium) and Polytrim (polymyxin b sulfate; trimethoprim sulfate). Common drug interactions include coronary artery occlusion among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Singulair and Polytrim. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

What is Polytrim?

Polytrim has active ingredients of polymyxin b sulfate; trimethoprim sulfate. eHealthMe is studying from 376 Polytrim users. Check the latest studies of Polytrim.

On Jul, 26, 2026

24 people who take Singulair and Polytrim together, and have interactions are studied.

Singulair and Polytrim drug interactions.

What are the common drug interactions of Singulair and Polytrim, by gender? *:

female:

Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ear infection
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Multiple fractures

male:

Drug ineffective
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Nail infection
Onychomadesis (a periodic idiopathic shedding of the nails)
Pruritus (severe itching of the skin)
Rash
Sinusitis (inflammation of sinus)
Skin disorder (skin disease)
Chronic kidney disease
Renal failure (kidney dysfunction)

What are the common drug interactions of Singulair and Polytrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Ear infection
Urinary tract infection
Influenza
Sialoadenitis (inflammation of a salivary gland)
Sinusitis (inflammation of sinus)

20-29:

n/a

30-39:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

40-49:

Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Chronic kidney disease
Renal failure (kidney dysfunction)
Dry skin
Memory impairment
Pruritus (severe itching of the skin)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Pain
Death
Gait disturbance
General physical health deterioration (weak health status)

60+:

Abdominal distension
Abdominal pain
Feeding disorder (when children refuse to eat certain food groups)
Flushing (the warm, red condition of human skin)
Nausea (feeling of having an urge to vomit)
Pain
Protein urine present
Retching (strong involuntary effort to vomit)
Vomiting
Abdominal pain upper

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 41.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 37.50%
Pain: 4 people, 16.67%
High Blood Cholesterol: 3 people, 12.50%
Immunodeficiency: 3 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.50%
Weight Decreased: 2 people, 8.33%
Bacterial Infection: 2 people, 8.33%
Blood Potassium Decreased: 2 people, 8.33%
Bone Loss: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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