Sitagliptin phosphate and Diazepam drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Sitagliptin phosphate (sitagliptin phosphate) and Diazepam (diazepam). Common drug interactions include drug-induced liver injury among females and chronic kidney disease among males.
The phase IV clinical study analyzes what interactions people have when they take Sitagliptin phosphate and Diazepam. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.
What is Sitagliptin phosphate?
Sitagliptin phosphate has active ingredients of sitagliptin phosphate. eHealthMe is studying from 3,787 Sitagliptin phosphate users. Check the latest studies of Sitagliptin phosphate.
What is Diazepam?
Diazepam has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 108,384 Diazepam users. Check the latest studies of Diazepam.
22 people who take Sitagliptin phosphate and Diazepam together, and have interactions are studied.

What are the common drug interactions of Sitagliptin Phosphate and Diazepam, by gender? *:
female:
- Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
- Hyperglycaemia (high blood sugar)
- Hyperkalaemia (damage to or disease of the kidney)
- Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
- Urine output decreased
- Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
- Hepatic necrosis (large portions of liver die off due to severe liver disease)
- Hepatitis (inflammation of the liver)
- Hepatotoxicity (chemical-driven liver damage)
- Mixed liver injury
male:
- Chronic kidney disease
- Renal failure (kidney dysfunction)
- Neoplasm malignant (cancer tumour)
- Obesity (having too much body fat)
- Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
- Renal injury (kidney injury)
- Benign prostatic hyperplasia (benign enlargement of the prostate)
- Cardiac failure
- Cardiac failure congestive
- Constipation
What are the common drug interactions of Sitagliptin Phosphate and Diazepam, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Blepharitis (chronic inflammation of the eyelid)
- Blindness
- Endophthalmitis (inflammation of the internal coats of the eye)
- Eye pain
- Keratitis (eye's cornea, the front part of the eye, becomes inflamed)
- Visual acuity reduced (reduced clearness of vision)
- Vitritis (inflammation of the vitreous humour of the eye)
- Anaemia (lack of blood)
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Diarrhoea
60+:
- Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
- Hyperglycaemia (high blood sugar)
- Urine output decreased
- Acidosis (build-up of carbon dioxide in the blood)
- Cardiac murmur (an heart sound in valve abnormality)
- Dehydration (dryness resulting from the removal of water)
- Hepatocellular injury (liver injury)
- Oedema peripheral (superficial swelling)
- Hepatitis toxic
- Cholestatic liver injury (due to injury bile cannot floe from liver)
What are the existing conditions these people have? *
- Type 2 Diabetes: 5 people, 22.73%
- Itching: 4 people, 18.18%
- Hyperuricaemia (level of uric acid in the blood that is abnormally high): 4 people, 18.18%
- Pain: 2 people, 9.09%
- Muscle Spasms (muscle contraction): 2 people, 9.09%
- Multiple Myeloma (cancer of the plasma cells): 2 people, 9.09%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.09%
- Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 9.09%
- Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 2 people, 9.09%
* Approximation only. Some reports may have incomplete information.
Do you take Sitagliptin phosphate and Diazepam?
- Personalize this study to your gender, age, symptoms and drugs
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Sitagliptin phosphate (3,787 reports)
- Diazepam (108,384 reports)
Browse all drug interactions of Sitagliptin phosphate and Diazepam:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Sitagliptin phosphate:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Diazepam:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Sitagliptin phosphate and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Diazepam and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan", European journal of internal medicine, 2016 Jan .
- Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment", Journal of family medicine and primary care, 2014 Jan .
- Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
- Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia?)", Dermatology online journal, 2012 Feb .
- Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan", European journal of internal medicine, 2016 Jan .
- Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment", Journal of family medicine and primary care, 2014 Jan .
- Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
- Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia?)", Dermatology online journal, 2012 Feb .
How the study uses the data?
The study uses data from the FDA. It is based on sitagliptin phosphate and diazepam (the active ingredients of Sitagliptin phosphate and Diazepam, respectively), and Sitagliptin phosphate and Diazepam (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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