Skyla and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Skyla (levonorgestrel) and Profen (ibuprofen). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Skyla and Profen. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Skyla?

Skyla has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 5,452 Skyla users. Check the latest studies of Skyla.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 06, 2026

32 people who take Skyla and Profen together, and have interactions are studied.

What are the common drug interactions of Skyla and Profen, by gender? *:

female:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Pregnancy with contraceptive device
Procedural pain
Stress
Abdominal pain lower
Abortion spontaneous (naturally occurring miscarriage)
Drug ineffective
Ill-defined disorder
Abdominal pain

male:

n/a

What are the common drug interactions of Skyla and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Aphasia (damage to the parts of the brain that control language)
Dysarthria (speech disorder)
Dysgraphia (impaired ability to learn to write)
Tremor (trembling or shaking movements in one or more parts of your body)
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Stress
Ill-defined disorder

20-29:

Abortion spontaneous incomplete (an incomplete spontaneous abortion means that some of the pregnancy tissue has passed out of the uterus, but some of the tissue has remained inside of the uterus)
Coital bleeding (bleeding after sexual intercourse)
Dyspareunia (painful sexual intercourse)
Emotional distress
Genital discharge
Haemorrhage in pregnancy (bleeding in pregnancy)
Menstruation irregular
Metrorrhagia (uterine bleeding at irregular intervals)
Migraine (headache)
Nausea (feeling of having an urge to vomit)

30-39:

Physical assault
Sleep terror (felling of terror in sleep)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 40.62%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 37.50%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 3 people, 9.38%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 2 people, 6.25%
Myeloid Leukaemia (a type of cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 6.25%
Migraine (headache): 2 people, 6.25%
Drowsiness: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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