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Sofosbuvir and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sofosbuvir (sofosbuvir) and Methotrexate (methotrexate sodium). Common drug interactions include cholestasis among females and cytomegalovirus infection among males.

The phase IV clinical study analyzes what interactions people have when they take Sofosbuvir and Methotrexate. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Sofosbuvir?

Sofosbuvir has active ingredients of sofosbuvir. eHealthMe is studying from 9,194 Sofosbuvir users. Check the latest studies of Sofosbuvir.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 19, 2026

16 people who take Sofosbuvir and Methotrexate together, and have interactions are studied.

Sofosbuvir and Methotrexate drug interactions.

What are the common drug interactions of Sofosbuvir and Methotrexate, by gender? *:

female:

  1. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  2. Hepatic enzyme increased

male:

  1. Cytomegalovirus infection
  2. Soft tissue infection
  3. Bacterial sepsis
  4. Pneumonia
  5. Respiratory failure (inadequate gas exchange by the respiratory system)
  6. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  7. Septic shock (shock due to blood infection)

What are the common drug interactions of Sofosbuvir and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Cytomegalovirus infection
  2. Soft tissue infection

20-29:

n/a

30-39:

  1. Bacterial sepsis

40-49:

  1. Pneumonia
  2. Respiratory failure (inadequate gas exchange by the respiratory system)
  3. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  4. Septic shock (shock due to blood infection)

50-59:

  1. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  2. Hepatic enzyme increased

60+:

n/a

What are the existing conditions these people have? *

  1. Hepatitis C: 8 people, 50.00%
  2. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 7 people, 43.75%
  3. Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 31.25%
  4. Burkitt's Lymphoma (cancer of the lymphatic system): 2 people, 12.50%
  5. Stress And Anxiety: 1 person, 6.25%
  6. Renal Disorder (kidney disease): 1 person, 6.25%
  7. Pain: 1 person, 6.25%
  8. Nausea And Vomiting: 1 person, 6.25%
  9. Nausea (feeling of having an urge to vomit): 1 person, 6.25%
  10. Hepatitis Viral: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Sofosbuvir and Methotrexate?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sofosbuvir and Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sofosbuvir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sofosbuvir and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methotrexate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sofosbuvir and methotrexate sodium (the active ingredients of Sofosbuvir and Methotrexate, respectively), and Sofosbuvir and Methotrexate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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