Sofosbuvir and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sofosbuvir (sofosbuvir) and Zantac (ranitidine hydrochloride). Common drug interactions include renal impairment among females and chronotropic incompetence among males.

The phase IV clinical study analyzes what interactions people have when they take Sofosbuvir and Zantac. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Sofosbuvir?

Sofosbuvir has active ingredients of sofosbuvir. eHealthMe is studying from 9,194 Sofosbuvir users. Check the latest studies of Sofosbuvir.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Jul, 19, 2026

55 people who take Sofosbuvir and Zantac together, and have interactions are studied.

Sofosbuvir and Zantac drug interactions.

What are the common drug interactions of Sofosbuvir and Zantac, by gender? *:

female:

Renal impairment (severely reduced kidney function)
General physical health deterioration (weak health status)
Death
Hospitalisation
Renal failure (kidney dysfunction)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Arthralgia (joint pain)
Cardiac failure
Cellulitis (infection under the skin)

male:

Chronotropic incompetence (inability of the heart to increase its rate appropriately in response to increased activity or metabolic need)
Dehydration (dryness resulting from the removal of water)
Chest pain
Confusional state
Depression
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Haematocrit decreased
Haemoglobin decreased
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

What are the common drug interactions of Sofosbuvir and Zantac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Cellulitis (infection under the skin)
Depression
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Increased appetite
Insomnia (sleeplessness)
Irritability
Photosensitivity reaction
Presyncope
Sunburn

50-59:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Chronic kidney disease
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Lung adenocarcinoma (a form of non-small cell lung cancer)
Migraine (headache)
Nephrogenic anaemia (anaemia due to kidney disease)
Pain
Procedural pain

60+:

Renal impairment (severely reduced kidney function)
General physical health deterioration (weak health status)
Balance disorder
Blood urea increased
Cardiac failure
Chest discomfort
Chest pain
Chronic kidney disease
Confusional state
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Hepatitis C: 49 people, 89.09%
Hepatocellular Carcinoma (liver cancer): 21 people, 38.18%

* Approximation only. Some reports may have incomplete information.

Do you take Sofosbuvir and Zantac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously