Soliris and Ortho evra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soliris (eculizumab) and Ortho evra (ethinyl estradiol; norelgestromin). Common drug interactions include contusion among females.

The phase IV clinical study analyzes what interactions people have when they take Soliris and Ortho evra. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

What is Ortho evra?

Ortho evra has active ingredients of ethinyl estradiol; norelgestromin. It is often used in birth control. eHealthMe is studying from 29,275 Ortho evra users. Check the latest studies of Ortho evra.

On Jul, 18, 2026

15 people who take Soliris and Ortho evra together, and have interactions are studied.

Soliris and Ortho evra drug interactions.

What are the common drug interactions of Soliris and Ortho Evra, by gender? *:

female:

Contusion (a type of hematoma of tissue in which capillaries)
Hypersensitivity
Adverse event
Antibiotic therapy
Liver disorder (liver diseases)
Metrorrhagia (uterine bleeding at irregular intervals)
Depression
Nausea (feeling of having an urge to vomit)
Presyncope
Dyspnoea (difficult or laboured respiration)

male:

n/a

What are the common drug interactions of Soliris and Ortho Evra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Adverse event
Antibiotic therapy
Haematocrit decreased
Haemoglobin decreased
Liver disorder (liver diseases)
Metrorrhagia (uterine bleeding at irregular intervals)

20-29:

Contusion (a type of hematoma of tissue in which capillaries)
Hypersensitivity
Poor venous access
Colitis (inflammation of colon)
Impaired gastric emptying
Oesophagitis (inflammation of oesophagus)
Irritable bowel syndrome
Depression
Nausea (feeling of having an urge to vomit)
Presyncope

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate increased
Maternal exposure during pregnancy (use of substance during pregnancy)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pallor

40-49:

n/a

50-59:

n/a

60+:

Abasia (inability to walk)
Back pain
Influenza like illness
Infusion related reaction
Irritable bowel syndrome
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oesophagitis (inflammation of oesophagus)
Pain
Poor venous access
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 15 people, 100.00%
Pain: 9 people, 60.00%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 7 people, 46.67%
Insomnia (sleeplessness): 3 people, 20.00%
Depression: 2 people, 13.33%
Thyroid Diseases: 1 person, 6.67%
Stress And Anxiety: 1 person, 6.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%
Pre-Eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman): 1 person, 6.67%
Nausea (feeling of having an urge to vomit): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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