Soliris and Senna drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soliris (eculizumab) and Senna (senna). Common drug interactions include thrombocytopenia among females and chest discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Soliris and Senna. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

84 people who take Soliris and Senna together, and have interactions are studied.

What are the common drug interactions of Soliris and Senna, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Contusion (a type of hematoma of tissue in which capillaries)
Apathy
Depressed mood
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Poor quality sleep
Pain
Anaemia (lack of blood)
Epistaxis (bleed from the nose)
Lethargy (tiredness)

male:

Chest discomfort
Vomiting
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Oedema (fluid collection in tissue)
Hypertension (high blood pressure)
Chest pain
Infusion site bruising
Infusion site discolouration
Infusion site pain

What are the common drug interactions of Soliris and Senna, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Basal ganglia infarction (disruption of the blood flow in the small blood vessels in the white matter of the cerebral cortex)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalitis (inflammation of the brain)
Epistaxis (bleed from the nose)
Fluid overload (too much fluid in the blood)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Headache (pain in head)
Herpes simplex (herpes simplex is a common viral infection)
Hypertension (high blood pressure)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)

20-29:

Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain
Back pain
Chest discomfort
Dehydration (dryness resulting from the removal of water)
Drug intolerance (drug sensitivity)
Febrile neutropenia (fever with reduced white blood cells)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)

30-39:

Abdominal abscess (collection of pus in abdomen)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cellulitis (infection under the skin)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Alopecia (absence of hair from areas of the body)
Balance disorder
Dyspepsia (indigestion)
Fall
Fatigue (feeling of tiredness)
Headache (pain in head)

40-49:

Poor venous access
Dyspnoea (difficult or laboured respiration)
Apathy
Depressed mood
Dyspnoea exertional (breathlessness or shortness of breath)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Fatigue (feeling of tiredness)
Oedema (fluid collection in tissue)
Poor quality sleep
Urinary tract infection

50-59:

Depressed mood
Depression suicidal (suicide depressive disorder)
Device occlusion
Dizziness
Electrolyte imbalance
Fall
Fluid overload (too much fluid in the blood)
Hallucination, visual (seeing things that aren't there)
Hypertension (high blood pressure)
Hypoacusis (loss of hearing)

60+:

Thrombocytopenia (decrease of platelets in blood)
Fatigue (feeling of tiredness)
Glomerular filtration rate decreased
Haematocrit decreased
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Blood lactate dehydrogenase increased
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 42 people, 50.00%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 21 people, 25.00%
Pain: 20 people, 23.81%
High Blood Pressure: 10 people, 11.90%
Nausea (feeling of having an urge to vomit): 8 people, 9.52%
Antiphospholipid Syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss): 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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