Soliris and Vitamin d3 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soliris (eculizumab) and Vitamin d3 (cholecalciferol). Common drug interactions include intervertebral disc protrusion among females and haemoglobin decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Soliris and Vitamin d3. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

What is Vitamin d3?

Vitamin d3 has active ingredients of cholecalciferol. It is often used in heart health. eHealthMe is studying from 32,171 Vitamin d3 users. Check the latest studies of Vitamin d3.

On Jul, 19, 2026

80 people who take Soliris and Vitamin d3 together, and have interactions are studied.

Soliris and Vitamin d3 drug interactions.

What are the common drug interactions of Soliris and Vitamin D3, by gender? *:

female:

Intervertebral disc protrusion (spinal disc protrusion)
Lethargy (tiredness)
Poor venous access
Vomiting
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anaemia (lack of blood)
Influenza
Nausea (feeling of having an urge to vomit)
Rhinorrhoea (watery mucus discharge from the nose)
Depression

male:

Haemoglobin decreased
Pneumonia
Meningitis enterococcal (fungal inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Paroxysmal nocturnal haemoglobinuria (haemoglobin in the urine)
Pyrexia (fever)
Rash
Staphylococcal bacteraemia (a bacterial infection of blood)
Abdominal pain
Hypervolaemia (abnormally increased volume of blood)

What are the common drug interactions of Soliris and Vitamin D3, by age (0-1 to 60+)? *:

0-1:

Constipation
Hypertension (high blood pressure)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Weight decreased

2-9:

Hospitalisation
Blood creatinine increased
Dehydration (dryness resulting from the removal of water)
Haemoglobin decreased
Platelet count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)

10-19:

Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Suicidal ideation
Basal ganglia infarction (disruption of the blood flow in the small blood vessels in the white matter of the cerebral cortex)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalitis (inflammation of the brain)
Epistaxis (bleed from the nose)
Fluid overload (too much fluid in the blood)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Headache (pain in head)

20-29:

Pneumonia
Abdominal pain
Fatigue (feeling of tiredness)
Cardiomyopathy (weakening of the heart muscle)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Meningitis enterococcal (fungal inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Paroxysmal nocturnal haemoglobinuria (haemoglobin in the urine)
Staphylococcal bacteraemia (a bacterial infection of blood)

30-39:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Fatigue (feeling of tiredness)
Headache (pain in head)
Increased appetite
Viral infection
Vomiting
Abdominal distension
Back pain

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Blood lactate dehydrogenase increased
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Cough
Device occlusion
Dyspnoea (difficult or laboured respiration)
Extravascular haemolysis
Eye disorder
Gingival bleeding (bleeding gums)

60+:

Haemoglobin decreased
Fatigue (feeling of tiredness)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cellulitis (infection under the skin)
Haemorrhage (bleeding)
Lethargy (tiredness)
Poor venous access
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Headache (pain in head)
Rhinorrhoea (watery mucus discharge from the nose)

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 48 people, 60.00%
High Blood Pressure: 27 people, 33.75%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 24 people, 30.00%
Pain: 19 people, 23.75%
Indigestion: 13 people, 16.25%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 9 people, 11.25%
Itching: 8 people, 10.00%
Hypersensitivity: 8 people, 10.00%
Constipation: 6 people, 7.50%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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