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Solodyn and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Solodyn (minocycline hydrochloride - er) and Synthroid (levothyroxine sodium). Common drug interactions include contusion among females and deafness among males.

The phase IV clinical study analyzes what interactions people have when they take Solodyn and Synthroid. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Solodyn?

Solodyn has active ingredients of minocycline hydrochloride - er. It is often used in acne. eHealthMe is studying from 1,011 Solodyn users. Check the latest studies of Solodyn.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,205 Synthroid users. Check the latest studies of Synthroid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

13 people who take Solodyn and Synthroid together, and have interactions are studied.

Solodyn and Synthroid drug interactions.

What are the common drug interactions of Solodyn and Synthroid, by gender? *:

female:

  1. Contusion (a type of hematoma of tissue in which capillaries)
  2. Drug ineffective
  3. Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
  4. Immunosuppression
  5. Loss of consciousness
  6. Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
  7. Anxiety
  8. Application site burn
  9. Application site discolouration
  10. Application site discomfort

male:

  1. Deafness
  2. Dizziness
  3. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  4. Tinnitus (a ringing in the ears)
  5. Vomiting

What are the common drug interactions of Solodyn and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

20-29:

  1. Anxiety
  2. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  3. Emotional distress
  4. General physical health deterioration (weak health status)
  5. Injury
  6. Myocardial strain
  7. Pain
  8. Pulmonary embolism (blockage of the main artery of the lung)

30-39:

  1. Application site burn
  2. Application site discolouration
  3. Application site discomfort
  4. Application site erythema (redness of the skin at application site)
  5. Application site irritation
  6. Application site pain
  7. Application site papules (solid elevation of skin with no visible fluid at application site)
  8. Application site pruritus (application site severe itching of the skin)
  9. Application site swelling
  10. Application site urticaria

40-49:

  1. Deafness
  2. Dizziness
  3. Tinnitus (a ringing in the ears)
  4. Vomiting

50-59:

  1. Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
  2. Immunosuppression
  3. Loss of consciousness
  4. Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
  5. Arthralgia (joint pain)
  6. Non-small cell lung cancer (type of epithelial lung cancer)
  7. Rectal cancer (cancer of rectum)
  8. Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
  9. Bacteraemia (presence of bacteria in the blood)
  10. Herpes zoster

60+:

  1. Balance disorder
  2. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  3. Dyspnoea (difficult or laboured respiration)
  4. Pain in extremity

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 4 people, 30.77%
  2. Insomnia (sleeplessness): 3 people, 23.08%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 23.08%
  4. Depression: 3 people, 23.08%
  5. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 23.08%
  6. Pain: 3 people, 23.08%
  7. High Blood Pressure: 3 people, 23.08%
  8. Thyroid Diseases: 2 people, 15.38%
  9. Asthma: 2 people, 15.38%
  10. Cyst (a closed sac): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Solodyn and Synthroid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Solodyn and Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Solodyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Solodyn and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Synthroid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on minocycline hydrochloride - er and levothyroxine sodium (the active ingredients of Solodyn and Synthroid, respectively), and Solodyn and Synthroid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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