Solu-cortef and Azelastine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Solu-cortef (hydrocortisone sodium succinate) and Azelastine (azelastine hydrochloride). Common drug interactions include hospitalisation among females and chest discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Solu-cortef and Azelastine. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,400 Azelastine users. Check the latest studies of Azelastine.

On Aug, 09, 2026

40 people who take Solu-cortef and Azelastine together, and have interactions are studied.

Solu-cortef and Azelastine drug interactions.

What are the common drug interactions of Solu-Cortef and Azelastine, by gender? *:

female:

Hospitalisation
Skin haemorrhage (bleeding into skin)
Surgery
Contusion (a type of hematoma of tissue in which capillaries)
Malaise (a feeling of general discomfort or uneasiness)
Breast cancer
Abdominal pain upper
Gastric haemorrhage (bleeding stomach)
Hypersensitivity
Seasonal allergy (allergic condition due to certain season)

male:

Chest discomfort
Infusion related reaction
Abdominal distension
Abdominal pain
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Blood glucose increased
Catheter site discharge

What are the common drug interactions of Solu-Cortef and Azelastine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chest discomfort
Cough
Dyspnoea (difficult or laboured respiration)
Induration (thickening of tissue)
Infusion site pruritus (severe itching at infusion site)
Infusion site urticaria (rash of round, red welts on the skin at infusion site)
Urticaria (rash of round, red welts on the skin that itch intensely)
Wheezing (a high-pitched whistling sound made while you breath)

30-39:

n/a

40-49:

Burning sensation
Erythema (redness of the skin)
Fall
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Hydrocephalus (water on the brain)
Hyperhidrosis (abnormally increased sweating)
Hypersomnia (excessive daytime sleepiness (eds))

50-59:

Fall
Pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Burning sensation
Cold sweat
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance

60+:

Sinusitis (inflammation of sinus)
Infection
Infusion related reaction
Pain
Spinal stenosis (narrowing of spinal column)
Breast cancer
Abdominal pain upper
Gastric haemorrhage (bleeding stomach)
Hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 23 people, 57.50%
Dehydration (dryness resulting from the removal of water): 6 people, 15.00%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 5 people, 12.50%
Primary Immunodeficiency Syndrome: 4 people, 10.00%
Pain: 4 people, 10.00%
Immunodeficiency: 4 people, 10.00%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 7.50%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 5.00%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 5.00%
Seizure Cluster (small group of seizure): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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