Solu-cortef and Sandimmune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Solu-cortef (hydrocortisone sodium succinate) and Sandimmune (cyclosporine). Common drug interactions include hypertension among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Solu-cortef and Sandimmune. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

What is Sandimmune?

Sandimmune has active ingredients of cyclosporine. eHealthMe is studying from 6,694 Sandimmune users. Check the latest studies of Sandimmune.

On Jul, 27, 2026

63 people who take Solu-cortef and Sandimmune together, and have interactions are studied.

Solu-cortef and Sandimmune drug interactions.

What are the common drug interactions of Solu-Cortef and Sandimmune, by gender? *:

female:

Hypertension (high blood pressure)
Impaired healing
Pain
Subcutaneous abscess
Thermal burn (burn by heat)
Urticaria (rash of round, red welts on the skin that itch intensely)
Blood lactate dehydrogenase increased
Blood urea increased
Oxygen saturation decreased
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)

male:

Renal failure acute (rapid kidney dysfunction)
Diarrhoea
Hypertension (high blood pressure)
Myopathy (a muscular disease in which the muscle fibres do not function)
Cardiac arrest
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Fungus serology test positive
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Solu-Cortef and Sandimmune, by age (0-1 to 60+)? *:

0-1:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Diarrhoea
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Oedema (fluid collection in tissue)
Pyrexia (fever)

2-9:

Headache (pain in head)
Abdominal pain
Depressed level of consciousness
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Somnolence (a state of near-sleep, a strong desire for sleep)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Fatigue (feeling of tiredness)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)

10-19:

Histiocytosis haematophagic
Hypertension (high blood pressure)
Impaired healing
Subcutaneous abscess
Thermal burn (burn by heat)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Febrile neutropenia (fever with reduced white blood cells)
Hepatic vein occlusion (blockage of the hepatic vein)
Pericardial effusion (fluid around the heart)
Pulmonary oedema (fluid accumulation in the lungs)

20-29:

Abdominal pain
Abnormal sensation in eye
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood lactate dehydrogenase increased
Blood urea increased

30-39:

Blood pressure increased
Brain natriuretic peptide increased
Capillary permeability increased (increased ability of small blood vessels to pass fluid in and out)
Chest discomfort
Chest pain
Depressed level of consciousness
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hyperventilation
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Immunosuppressant drug level increased

40-49:

Arthralgia (joint pain)
Drug ineffective
Feeling cold
Hypersensitivity
Infection
Infusion related reaction
Joint stiffness
Joint swelling
Pruritus (severe itching of the skin)
Skin disorder (skin disease)

50-59:

Diarrhoea
Hyperkalaemia (damage to or disease of the kidney)
Renal failure acute (rapid kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Myopathy (a muscular disease in which the muscle fibres do not function)
Cardiac arrest
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Fungus serology test positive
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)

60+:

Psychotic disorder
Acute circulatory failure (shock)
Pain
Renal failure (kidney dysfunction)
Respiratory disorder (respiratory disease)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bladder discomfort
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 8 people, 12.70%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 12.70%
Immunodeficiency Disorders: 7 people, 11.11%
Muscle Aches (muscle pain): 6 people, 9.52%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 6 people, 9.52%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 5 people, 7.94%
High Blood Cholesterol: 5 people, 7.94%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 5 people, 7.94%
Fungal Infection: 4 people, 6.35%
Allergies: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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