Solu-medrol and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Solu-medrol (methylprednisolone sodium succinate) and Sinemet (carbidopa; levodopa). Common drug interactions include mood altered among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Solu-medrol and Sinemet. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Solu-medrol?

Solu-medrol has active ingredients of methylprednisolone sodium succinate. It is often used in multiple sclerosis. eHealthMe is studying from 39,410 Solu-medrol users. Check the latest studies of Solu-medrol.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 07, 2026

15 people who take Solu-medrol and Sinemet together, and have interactions are studied.

Solu-medrol and Sinemet drug interactions.

What are the common drug interactions of Solu-Medrol and Sinemet, by gender? *:

female:

Mood altered (changes in mood)
Pain
Pain in extremity
Screaming (a long loud piercing cry)
Sepsis (a severe blood infection that can lead to organ failure and death)
Speech disorder
Subdural haematoma (blood collects between the skull and the surface of the brain)
Thrombocytopenia (decrease of platelets in blood)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrioventricular block first degree (heart block first degree)
Atrioventricular block second degree (heart block second degree)
Blood glucose increased
Blood pressure diastolic decreased
Breath sounds

What are the common drug interactions of Solu-Medrol and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diarrhoea
Weight decreased

50-59:

Alopecia (absence of hair from areas of the body)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Urinary tract infection
Anaphylactic reaction (serious allergic reaction)
Apnoea (suspension of external breathing)
Blood glucose decreased
Cardiomyopathy (weakening of the heart muscle)
Coagulopathy (blood's ability to clot is impaired)
Confusion
Cough
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)

What are the existing conditions these people have? *

Urinary Tract Infection: 2 people, 13.33%
Stress And Anxiety: 2 people, 13.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 13.33%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 2 people, 13.33%
Constipation: 2 people, 13.33%
Prostatic Disorder: 1 person, 6.67%
Memory Loss: 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
Diabetes: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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