Sonata and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sonata (zaleplon) and Actonel (risedronate sodium). Common drug interactions include cardiac failure congestive among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Sonata and Actonel. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 16, 2026

39 people who take Sonata and Actonel together, and have interactions are studied.

What are the common drug interactions of Sonata and Actonel, by gender? *:

female:

Cardiac failure congestive
Cardioactive drug level below therapeutic
Chest pain
Completed suicide (act of taking one's own life)
Decreased appetite
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dementia (madness)
Discomfort
Dizziness
Drug administration error

male:

Chronic kidney disease
Fall
Femur fracture
Fracture delayed union (delayed cure of broken bone)
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Groin pain
Haematoma (collection of blood outside the blood vessels)
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Mass

What are the common drug interactions of Sonata and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Depression
Overdose
Suicide attempt

30-39:

Arthralgia (joint pain)
Bone disorder
Dysstasia (difficulty in standing)
Femur fracture
Fracture delayed union (delayed cure of broken bone)
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Groin pain
Haematoma (collection of blood outside the blood vessels)
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)

40-49:

n/a

50-59:

Dysstasia (difficulty in standing)
Exostosis (formation of new bone on the surface of a bone)
Fracture delayed union (delayed cure of broken bone)
Gingival infection (gum infection)
Haematoma (collection of blood outside the blood vessels)
Hypoaesthesia facial (reduced sense of touch or sensation on face)
Hypophagia (reduced food intake)
Immunosuppression
Jaw disorder (jaw disease)
Jaw fracture

60+:

Candiduria (candida in urine)
Dehydration (dryness resulting from the removal of water)
Fall
Hip fracture
Nodule on extremity (a small rock or mineral cluster on hands or legs)
Pathogen resistance
Asthenia (weakness)
Atrioventricular block second degree (heart block second degree)
Bradycardia (abnormally slow heart action)
Cardiac asthma (wheezing, coughing or shortness of breath due to congestive heart failure)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 33.33%
High Blood Cholesterol: 11 people, 28.21%
Asthma: 10 people, 25.64%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 23.08%
High Blood Pressure: 9 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 20.51%
Inflammation: 7 people, 17.95%
Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 17.95%
Neuropathy Peripheral (surface nerve damage): 7 people, 17.95%
Hypersensitivity: 7 people, 17.95%

* Approximation only. Some reports may have incomplete information.

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