Sorafenib and Lorazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sorafenib (sorafenib) and Lorazepam (lorazepam). Common drug interactions include drug ineffective among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Sorafenib and Lorazepam. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Sorafenib?

Sorafenib has active ingredients of sorafenib. eHealthMe is studying from 3,201 Sorafenib users. Check the latest studies of Sorafenib.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

30 people who take Sorafenib and Lorazepam together, and have interactions are studied.

Sorafenib and Lorazepam drug interactions.

What are the common drug interactions of Sorafenib and Lorazepam, by gender? *:

female:

Drug ineffective
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fatigue (feeling of tiredness)
Incisional drainage
Liver disorder (liver diseases)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nodule (a growth of abnormal tissue)
Overdose
Pulmonary embolism (blockage of the main artery of the lung)
Skin lesion

male:

Pneumonia
Death
Lung disorder (lung disease)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Alanine aminotransferase increased
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Diplegia (paralysis of corresponding parts on both sides of the body)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Urinary retention (the inability to completely or partially empty the bladder)

What are the common drug interactions of Sorafenib and Lorazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Hypotension (abnormally low blood pressure)
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Nausea (feeling of having an urge to vomit)
Rash
Anal abscess
Drug ineffective
Febrile neutropenia (fever with reduced white blood cells)
Incisional drainage
Lymphadenopathy (disease or enlargement of lymph nodes)

30-39:

n/a

40-49:

Aspergilloma (fungus ball, is a clump of fungus which exists in a body cavity such as the lung)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Migraine (headache)
Mitral valve incompetence (inefficient heart valve)
Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Death
Headache (pain in head)
Alanine aminotransferase increased
Anaemia (lack of blood)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Diplegia (paralysis of corresponding parts on both sides of the body)

60+:

Pneumonia
Asthenia (weakness)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypoxia (low oxygen in tissues)
Lung disorder (lung disease)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Tremor (trembling or shaking movements in one or more parts of your body)
Acute respiratory distress syndrome

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 8 people, 26.67%
Pain: 4 people, 13.33%
Nausea (feeling of having an urge to vomit): 4 people, 13.33%
Insomnia (sleeplessness): 4 people, 13.33%
Nausea And Vomiting: 3 people, 10.00%
Hepatocellular Carcinoma (liver cancer): 3 people, 10.00%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 2 people, 6.67%
Pancreatic Carcinoma (pancreatic cancer): 2 people, 6.67%
Neoplasm Malignant (cancer tumour): 2 people, 6.67%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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