Sorafenib and Midostaurin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sorafenib (sorafenib) and Midostaurin (midostaurin). Common drug interactions include febrile neutropenia among females and pancytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Sorafenib and Midostaurin. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Sorafenib?

Sorafenib has active ingredients of sorafenib. eHealthMe is studying from 3,201 Sorafenib users. Check the latest studies of Sorafenib.

What is Midostaurin?

Midostaurin has active ingredients of midostaurin. eHealthMe is studying from 1,137 Midostaurin users. Check the latest studies of Midostaurin.

On Jul, 13, 2026

40 people who take Sorafenib and Midostaurin together, and have interactions are studied.

Sorafenib and Midostaurin drug interactions.

What are the common drug interactions of Sorafenib and Midostaurin, by gender? *:

female:

Febrile neutropenia (fever with reduced white blood cells)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Bacteraemia (presence of bacteria in the blood)
Colitis (inflammation of colon)
Drug ineffective
Empyema (collection of pus in a cavity in the body)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypoglycaemia (deficiency of glucose in the bloodstream)

male:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Device related infection
Diarrhoea
Drug ineffective
Headache (pain in head)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Urinary tract infection

What are the common drug interactions of Sorafenib and Midostaurin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Bone marrow failure
Drug intolerance (drug sensitivity)
Lymphadenopathy (disease or enlargement of lymph nodes)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Skin toxicity (skin damage due to toxin/poison)
Myelosuppression (a decrease in the production of blood cells)

10-19:

Alanine aminotransferase increased
Bacteraemia (presence of bacteria in the blood)
Drug ineffective
Febrile neutropenia (fever with reduced white blood cells)
Acidosis (build-up of carbon dioxide in the blood)
Haemorrhage intracranial (bleeding within the skull)
Pneumonia fungal
Anaemia (lack of blood)
Thrombocytopenia (decrease of platelets in blood)
Blood creatinine increased

20-29:

Anaemia (lack of blood)
Drug ineffective
Febrile neutropenia (fever with reduced white blood cells)
Thrombocytopenia (decrease of platelets in blood)
Death
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)

30-39:

Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Septal panniculitis (a condition of the subcutaneous fat affecting the layer of adipose tissue that lies between the dermis and underlying fascia)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Drug ineffective

40-49:

Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Device related infection
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Headache (pain in head)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)

50-59:

Acute myocardial infarction (acute heart attack)
Asthenia (weakness)
Bacteraemia (presence of bacteria in the blood)
Duodenal ulcer
Endocarditis (inflammation in heart muscle)
Epistaxis (bleed from the nose)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyporesponsive to stimuli (abnormally low degree of responsiveness on an agent, action, or condition)
Hypotension (abnormally low blood pressure)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)

60+:

Febrile neutropenia (fever with reduced white blood cells)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Vaginal haemorrhage (vaginal bleeding)
Bacteraemia (presence of bacteria in the blood)
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Oliguria (not enough urine)
Staphylococcal infection (an infection with staphylococcus bacteria)
Colitis (inflammation of colon)
Empyema (collection of pus in a cavity in the body)
Hyperbilirubinaemia (excess of bilirubin in the blood)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 36 people, 90.00%
Bone Marrow Conditioning Regimen: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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