Sotret and Lorazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sotret (isotretinoin) and Lorazepam (lorazepam). Common drug interactions include depression among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Sotret and Lorazepam. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Sotret?

Sotret has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 9,024 Sotret users. Check the latest studies of Sotret.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

21 people who take Sotret and Lorazepam together, and have interactions are studied.

What are the common drug interactions of Sotret and Lorazepam, by gender? *:

female:

Depression
Nausea (feeling of having an urge to vomit)
Drug dependence
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Psychotic behaviour
Rash
Suicidal ideation

male:

Completed suicide (act of taking one's own life)
Depression
Abdominal pain
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Gallbladder cancer
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrointestinal oedema (excessive build-up of fluid in the gastrointestinal tract tissues)

What are the common drug interactions of Sotret and Lorazepam, by age (0-1 to 60+)? *:

0-1:

Abnormal behaviour
Depression
Mood altered (changes in mood)

2-9:

Anaemia (lack of blood)
Febrile neutropenia (fever with reduced white blood cells)
Hypokalaemia (low potassium)
Bacteraemia (presence of bacteria in the blood)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
White blood cell count decreased
Device related infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Hyperbilirubinaemia (excess of bilirubin in the blood)

10-19:

Depression
Completed suicide (act of taking one's own life)
Mood swings (an extreme or rapid change in mood)
Panic attack
Sluggishness (lacking alertness)

20-29:

Drug dependence
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Psychotic behaviour
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)
Epistaxis (bleed from the nose)
Personality disorder
Psychotic disorder

30-39:

n/a

40-49:

Drug ineffective

50-59:

n/a

60+:

Abdominal pain
Anaemia (lack of blood)
Irritable bowel syndrome
Neoplasm malignant (cancer tumour)
Rectal haemorrhage (bleeding from anus)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Diarrhoea
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Depression: 6 people, 28.57%
Pain: 3 people, 14.29%
Neuroblastoma (a cancer that forms in your nerve tissue): 2 people, 9.52%
Nausea (feeling of having an urge to vomit): 2 people, 9.52%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 9.52%
Medulloblastoma (a fast-growing, high-grade tumour that always begins in the cerebellum): 2 people, 9.52%
Bipolar Disorder (mood disorder): 2 people, 9.52%
Asthma: 2 people, 9.52%
Acne Cystic (skin problems that cause pimples): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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