Sotret and Sertraline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sotret (isotretinoin) and Sertraline (sertraline hydrochloride). Common drug interactions include contusion among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Sotret and Sertraline. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Sotret?

Sotret has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 9,023 Sotret users. Check the latest studies of Sotret.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,304 Sertraline users. Check the latest studies of Sertraline.

On Jul, 08, 2026

60 people who take Sotret and Sertraline together, and have interactions are studied.

Sotret and Sertraline drug interactions.

What are the common drug interactions of Sotret and Sertraline, by gender? *:

female:

Contusion (a type of hematoma of tissue in which capillaries)
Night sweats (sweating in night)
Restless legs syndrome (a powerful urge to move your legs)
Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
Depressed mood
Abortion spontaneous (naturally occurring miscarriage)
Suicidal ideation
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Delusion (a false belief or opinion)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)

male:

Drug ineffective
Sapho syndrome (a disorder involving the skin, bone, and joints)
Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
Ear pain
Fungal infection
Genital lesion (sores, warts, or blemishes that appear on the genitals)
Groin pain
Hallucination (an experience involving the perception of something not present)
Hyperkeratosis (thickening of the outer layer of the skin)
Hypertension (high blood pressure)

What are the common drug interactions of Sotret and Sertraline, by age (0-1 to 60+)? *:

0-1:

Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
Depressive symptom
Drug ineffective
Insomnia (sleeplessness)
Irritability
Osteitis (a general term for inflammation of bone)
Sacroiliitis (an inflammation of the sacroiliac joint)
Sapho syndrome (a disorder involving the skin, bone, and joints)

2-9:

n/a

10-19:

Sapho syndrome (a disorder involving the skin, bone, and joints)
Depressive symptom
Drug ineffective
Insomnia (sleeplessness)
Irritability
Hypotension (abnormally low blood pressure)
Staphylococcal infection (an infection with staphylococcus bacteria)
Suicide attempt
Epistaxis (bleed from the nose)
Agitation (state of anxiety or nervous excitement)

20-29:

Contusion (a type of hematoma of tissue in which capillaries)
Night sweats (sweating in night)
Restless legs syndrome (a powerful urge to move your legs)
Suicidal ideation
Depressed mood
Delusion (a false belief or opinion)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Drug ineffective
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Maternal exposure during pregnancy (use of substance during pregnancy)

40-49:

Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)

50-59:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Thyroid disorder (thyroid diseases)
Arthralgia (joint pain)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Ear pain
Fungal infection
Genital lesion (sores, warts, or blemishes that appear on the genitals)
Groin pain
Hallucination (an experience involving the perception of something not present)

60+:

Cheilitis (infection of lips)
Disease recurrence
Photosensitivity reaction
Sarcoma metastatic (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues spreads to other parts)
Dyspepsia (indigestion)
Fall
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Herpes simplex (herpes simplex is a common viral infection)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the existing conditions these people have? *

Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 6 people, 10.00%
Stress And Anxiety: 5 people, 8.33%
Ill-Defined Disorder: 5 people, 8.33%
Depressive Symptom: 5 people, 8.33%
Acne Fulminans (acne with highly destructive inflammation-skin disease): 4 people, 6.67%
Acne Cystic (skin problems that cause pimples): 4 people, 6.67%
Nausea (feeling of having an urge to vomit): 3 people, 5.00%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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