Spironolactone and Genvoya drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spironolactone (spironolactone) and Genvoya (cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide fumarate). Common drug interactions include foot fracture among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Spironolactone and Genvoya. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Genvoya?

Genvoya has active ingredients of cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 13,538 Genvoya users. Check the latest studies of Genvoya.

On Jul, 18, 2026

53 people who take Spironolactone and Genvoya together, and have interactions are studied.

Spironolactone and Genvoya drug interactions.

What are the common drug interactions of Spironolactone and Genvoya, by gender? *:

female:

Foot fracture
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrolithiasis (calculi in the kidneys)
Protein urine present
Rash
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Weight increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress

male:

Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Diarrhoea
Drug ineffective
Asthenia (weakness)
Abdominal distension
Abdominal pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Bladder disorder

What are the common drug interactions of Spironolactone and Genvoya, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Depression
Dyspnoea (difficult or laboured respiration)
Emotional distress
Gait disturbance
Pain

30-39:

Anxiety
Bone density decreased
Emotional distress
Pain
Chronic kidney disease
Renal failure (kidney dysfunction)
Multiple fractures
Protein urine present
Tooth loss
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Osteoporosis (bones weak and more likely to break)
Osteopenia (a condition where bone mineral density is lower than normal)
Chronic kidney disease
Bone density decreased
Renal disorder (kidney disease)
Renal impairment (severely reduced kidney function)

50-59:

Peripheral swelling
Abdominal distension
Abdominal pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Back pain
Bladder disorder
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diarrhoea

60+:

Anaemia (lack of blood)
Pulmonary embolism (blockage of the main artery of the lung)
Blood creatinine increased
Oedema (fluid collection in tissue)
Adverse event
Chronic kidney disease
Hepatitis c
Hyperkalaemia (damage to or disease of the kidney)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Pain: 10 people, 18.87%
High Blood Pressure: 8 people, 15.09%
Cough: 8 people, 15.09%
Pneumonia: 5 people, 9.43%
Inflammation: 5 people, 9.43%
Herpes Zoster: 5 people, 9.43%
The Flu (the flu is caused by an influenza virus): 4 people, 7.55%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 7.55%
Rickets (softening of bones): 3 people, 5.66%
Infection: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and Genvoya?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously