Spironolactone and Injectafer drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spironolactone (spironolactone) and Injectafer (ferric carboxymaltose). Common drug interactions include insomnia among females and gout among males.

The phase IV clinical study analyzes what interactions people have when they take Spironolactone and Injectafer. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Injectafer?

Injectafer has active ingredients of ferric carboxymaltose. eHealthMe is studying from 3,270 Injectafer users. Check the latest studies of Injectafer.



On Jul, 26, 2026

41 people who take Spironolactone and Injectafer together, and have interactions are studied.

Spironolactone and Injectafer drug interactions.

What are the common drug interactions of Spironolactone and Injectafer, by gender? *:

female:

  1. Insomnia (sleeplessness)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
  4. Pain
  5. Abdominal pain
  6. Pain in extremity
  7. Impaired self-care
  8. Spinal compression fracture (fracture due to spinal compression on bone)
  9. Arthralgia (joint pain)
  10. Constipation

male:

  1. Gout (uric acid crystals building up in the body)
  2. Chest pain

What are the common drug interactions of Spironolactone and Injectafer, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Alopecia (absence of hair from areas of the body)
  2. Blood phosphorus decreased
  3. Dizziness

30-39:

  1. Drug hypersensitivity
  2. Headache (pain in head)

40-49:

  1. White blood cell count decreased
  2. Abdominal pain
  3. Cough
  4. Dizziness
  5. Headache (pain in head)
  6. Hospitalisation
  7. Hot flush (sudden feelings of heat)
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Vomiting

50-59:

  1. Chest pain
  2. Headache (pain in head)
  3. Nausea (feeling of having an urge to vomit)
  4. Vomiting

60+:

  1. Oedema peripheral (superficial swelling)
  2. Nausea (feeling of having an urge to vomit)
  3. Abdominal pain
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  5. Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
  6. Impaired self-care
  7. Pain
  8. Spinal compression fracture (fracture due to spinal compression on bone)
  9. Arthralgia (joint pain)
  10. Constipation

What are the existing conditions these people have? *

  1. Iron Deficiency Anaemia: 12 people, 29.27%
  2. Ovarian Cancer (cancer of ovary): 9 people, 21.95%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 21.95%
  4. Pain In Extremity: 8 people, 19.51%
  5. Cardiac Failure: 8 people, 19.51%
  6. Cough: 7 people, 17.07%
  7. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 17.07%
  8. Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 14.63%
  9. Nausea (feeling of having an urge to vomit): 6 people, 14.63%
  10. Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 6 people, 14.63%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Spironolactone and Injectafer:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Injectafer:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Spironolactone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Injectafer and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone and ferric carboxymaltose (the active ingredients of Spironolactone and Injectafer, respectively), and Spironolactone and Injectafer (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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