Spironolactone and Mircera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spironolactone (spironolactone) and Mircera (methoxy polyethylene glycol-epoetin beta). Common drug interactions include confusional state among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Spironolactone and Mircera. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Mircera?

Mircera has active ingredients of methoxy polyethylene glycol-epoetin beta. eHealthMe is studying from 10,321 Mircera users. Check the latest studies of Mircera.



On Jul, 11, 2026

84 people who take Spironolactone and Mircera together, and have interactions are studied.

Spironolactone and Mircera drug interactions.

What are the common drug interactions of Spironolactone and Mircera, by gender? *:

female:

  1. Confusional state
  2. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  3. Fall
  4. Fatigue (feeling of tiredness)
  5. General physical health deterioration (weak health status)
  6. Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
  7. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  8. Pallor
  9. Pneumonia
  10. Pruritus (severe itching of the skin)

male:

  1. Pneumonia
  2. Cardiac failure
  3. Large intestinal haemorrhage (bleeding in large intestine)
  4. Platelet count decreased
  5. Disseminated tuberculosis
  6. Periodontitis (inflammation of the tissue around the teeth)
  7. Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
  8. Death
  9. Dyspnoea (difficult or laboured respiration)
  10. Fatigue (feeling of tiredness)

What are the common drug interactions of Spironolactone and Mircera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug hypersensitivity
  2. Nausea (feeling of having an urge to vomit)
  3. Vomiting

40-49:

  1. Anaemia (lack of blood)
  2. Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

50-59:

  1. Emotional distress
  2. Fatigue (feeling of tiredness)
  3. Hyperkalaemia (damage to or disease of the kidney)
  4. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  5. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  6. Pruritus (severe itching of the skin)
  7. Renal impairment (severely reduced kidney function)
  8. Vitamin d deficiency
  9. Weight increased
  10. Blood uric acid increased

60+:

  1. Cardiac failure
  2. Pneumonia
  3. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  4. Angina pectoris (chest pain due to ischemia of the heart muscle)
  5. Blood urea increased
  6. Extremity necrosis (death of body tissue of arms and legs)
  7. Fall
  8. Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
  9. Iron deficiency anaemia
  10. Large intestinal haemorrhage (bleeding in large intestine)

What are the existing conditions these people have? *

  1. Nephrogenic Anaemia (anaemia due to kidney disease): 27 people, 32.14%
  2. Chronic Kidney Disease: 21 people, 25.00%
  3. Itching: 16 people, 19.05%
  4. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 12 people, 14.29%
  5. High Blood Pressure: 8 people, 9.52%
  6. Familial Mediterranean Fever (genetic disease recurring attacks of abdominal pain, fever, pleurisy, arthritis, and rash): 7 people, 8.33%
  7. Constipation: 7 people, 8.33%
  8. Insomnia (sleeplessness): 6 people, 7.14%
  9. Hyperuricaemia (level of uric acid in the blood that is abnormally high): 6 people, 7.14%
  10. High Blood Cholesterol: 6 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Spironolactone and Mircera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Mircera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Spironolactone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mircera and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone and methoxy polyethylene glycol-epoetin beta (the active ingredients of Spironolactone and Mircera, respectively), and Spironolactone and Mircera (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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