Spironolactone and Symlin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spironolactone (spironolactone) and Symlin (pramlintide acetate). Common drug interactions include gastrooesophageal reflux disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Spironolactone and Symlin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Symlin?

Symlin has active ingredients of pramlintide acetate. It is often used in diabetes. eHealthMe is studying from 3,359 Symlin users. Check the latest studies of Symlin.

On Jul, 26, 2026

24 people who take Spironolactone and Symlin together, and have interactions are studied.

Spironolactone and Symlin drug interactions.

What are the common drug interactions of Spironolactone and Symlin, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate irregular
Hyperhidrosis (abnormally increased sweating)
Hyperkalaemia (damage to or disease of the kidney)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Nausea (feeling of having an urge to vomit)
Weight increased
Dizziness
Vomiting

male:

Chronic kidney disease
Blood glucose decreased
Diarrhoea
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hunger
Leukocytosis (increased white blood cells)
Malaise (a feeling of general discomfort or uneasiness)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nausea (feeling of having an urge to vomit)
Peritoneal dialysis complication

What are the common drug interactions of Spironolactone and Symlin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Urticaria (rash of round, red welts on the skin that itch intensely)

30-39:

Chronic kidney disease
Depression
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

40-49:

Hyperglycaemia (high blood sugar)
Hypotension (abnormally low blood pressure)
Overdose
Pain
Perfume sensitivity
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory distress (difficulty in breathing)
Sluggishness (lacking alertness)
Suicide attempt

50-59:

Injection site pain

60+:

Nausea (feeling of having an urge to vomit)
Weight increased
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Injection site erythema (redness at injection site)
Injection site pain
Pulmonary hypertension (increase in blood pressure in the lung artery)
Vomiting
Abdominal pain

What are the existing conditions these people have? *

Type 2 Diabetes: 6 people, 25.00%
High Blood Cholesterol: 6 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 25.00%
Gout (uric acid crystals building up in the body): 4 people, 16.67%
Depression: 4 people, 16.67%
Thyroid Diseases: 3 people, 12.50%
Pain: 3 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 12.50%
Muscle Spasms (muscle contraction): 3 people, 12.50%
Kidney Stones: 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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