Sprintec and Amoxicillin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sprintec (ethinyl estradiol; norgestimate) and Amoxicillin (amoxicillin). Common drug interactions include bankruptcy among females and aortic valve incompetence among males.

The phase IV clinical study analyzes what interactions people have when they take Sprintec and Amoxicillin. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

70 people who take Sprintec and Amoxicillin together, and have interactions are studied.

Sprintec and Amoxicillin drug interactions.

What are the common drug interactions of Sprintec and Amoxicillin, by gender? *:

female:

Bankruptcy
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Blood pressure increased
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiogenic shock (inadequate circulation of blood)
Cellulitis (infection under the skin)
Chills (felling of cold)
Cholecystitis (infection of gallbladder)
Colitis (inflammation of colon)

male:

Aortic valve incompetence
Atrioventricular block first degree (heart block first degree)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Tricuspid valve incompetence (inefficient heart valve)
Upper respiratory tract infection
Cardiac arrest
Cardiac disorder
Drug abuse
Heart injury
Maternal exposure during pregnancy (use of substance during pregnancy)

What are the common drug interactions of Sprintec and Amoxicillin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal dreams
Alopecia (absence of hair from areas of the body)
Anxiety
Constipation
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Ear infection
Eye disorder
Fall

20-29:

Cellulitis (infection under the skin)
Chronic kidney disease
Cystitis (inflammation of the wall of the bladder)
Death
Dependence
Depression
Disability
Dry mouth
Ear pain
Emotional distress

30-39:

Aortic valve incompetence
Atrioventricular block first degree (heart block first degree)
Dilatation ventricular
Dyspnoea (difficult or laboured respiration)
Left ventricle outflow tract obstruction
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Mitral valve stenosis (narrowing of mitral valve)
Pericardial effusion (fluid around the heart)
Right atrial dilatation (enlargement of the right atrium chamber of heart)
Right ventricular hypertrophy (right ventricular enlargement)

40-49:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Sepsis (a severe blood infection that can lead to organ failure and death)
Chronic kidney disease
Blood urine present
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Protein urine
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

50-59:

Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemodynamic instability (disturbances in the blood movement in our body)
Hepatic failure (liver failure)
Hypotension (abnormally low blood pressure)
Lethargy (tiredness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 31.43%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 21.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 12.86%
Depression: 8 people, 11.43%
Stress And Anxiety: 8 people, 11.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 11.43%
Hypersensitivity: 7 people, 10.00%
Asthma: 7 people, 10.00%
Back Pain: 6 people, 8.57%
High Blood Pressure: 6 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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