Sprintec and Motrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sprintec (ethinyl estradiol; norgestimate) and Motrin (ibuprofen). Common drug interactions include cholelithiasis among females.

The phase IV clinical study analyzes what interactions people have when they take Sprintec and Motrin. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Motrin?

Motrin has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 38,332 Motrin users. Check the latest studies of Motrin.

On Aug, 09, 2026

53 people who take Sprintec and Motrin together, and have interactions are studied.

What are the common drug interactions of Sprintec and Motrin, by gender? *:

female:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Abdominal pain
Abdominal distension
Dysmenorrhoea (painful menstruation)
Lymphocyte count decreased
Uterine haemorrhage (uterine bleeding)
Abdominal pain lower
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)

male:

n/a

What are the common drug interactions of Sprintec and Motrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Biliary colic
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Abdominal pain lower
Back pain
Dyspnoea (difficult or laboured respiration)
Escherichia infection (bacterial infection by escherichia coli)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Heart rate increased
Hypertension (high blood pressure)

20-29:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder
Injury
Cholecystitis chronic (long lasting infection of gallbladder)
Vomiting
Abdominal pain
Abdominal pain upper
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Abdominal pain lower

30-39:

Migraine (headache)
Dizziness
Sinusitis (inflammation of sinus)
Abdominal pain
Abdominal pain lower
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Breast cancer

40-49:

Abdominal pain
Abdominal distension
Feeling of body temperature change
Malaise (a feeling of general discomfort or uneasiness)
Neuralgia (pain in one or more nerves)
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pancreatitis (inflammation of pancreas)
Device dislocation
Dysmenorrhoea (painful menstruation)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 11.32%
Immunodeficiency Common Variable: 6 people, 11.32%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 9.43%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 7.55%
Depression: 4 people, 7.55%
Premenstrual Syndrome: 3 people, 5.66%
Migraine Without Aura (headache without neurological problems): 3 people, 5.66%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 5.66%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 5.66%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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