Sprintec and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sprintec (ethinyl estradiol; norgestimate) and Ultram (tramadol hydrochloride). Common drug interactions include abdominal pain among females.

The phase IV clinical study analyzes what interactions people have when they take Sprintec and Ultram. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 23, 2026

14 people who take Sprintec and Ultram together, and have interactions are studied.

What are the common drug interactions of Sprintec and Ultram, by gender? *:

female:

Abdominal pain
Fatigue (feeling of tiredness)
Vomiting
Anxiety disorder
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Depression
Diarrhoea
Feeling of body temperature change
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)

male:

n/a

What are the common drug interactions of Sprintec and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Change of bowel habit
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Nausea (feeling of having an urge to vomit)
Vomiting

20-29:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Injection site rash

30-39:

Abdominal pain
Anxiety
Constipation
Cough
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Dizziness
Dysmenorrhoea (painful menstruation)
Dyspareunia (painful sexual intercourse)

40-49:

Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Anxiety disorder
Feeling of body temperature change
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Malaise (a feeling of general discomfort or uneasiness)
Neuralgia (pain in one or more nerves)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiorenal syndrome (kidney failure and heart failure)

50-59:

Abnormal behaviour
Burning sensation
Insomnia (sleeplessness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

60+:

n/a

What are the existing conditions these people have? *

Depression: 4 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 21.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 21.43%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 21.43%
Migraine Without Aura (headache without neurological problems): 3 people, 21.43%
Pelvic Pain: 2 people, 14.29%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%
Dysmenorrhea (painful menstruation): 1 person, 7.14%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 7.14%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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