Sps and Vitamin d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sps (sodium polystyrene sulfonate) and Vitamin d (ergocalciferol). Common drug interactions include anhedonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Sps and Vitamin d. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Sps?

Sps has active ingredients of sodium polystyrene sulfonate. eHealthMe is studying from 105 Sps users. Check the latest studies of Sps.

What is Vitamin d?

Vitamin d has active ingredients of ergocalciferol. It is often used in low vitamin d. eHealthMe is studying from 294,095 Vitamin d users. Check the latest studies of Vitamin d.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 02, 2026

15 people who take Sps and Vitamin d together, and have interactions are studied.

Sps and Vitamin d drug interactions.

What are the common drug interactions of Sps and Vitamin D, by gender? *:

female:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Chronic kidney disease
  4. Depression
  5. Diarrhoea
  6. Emotional distress
  7. Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
  8. Muscle spasms (muscle contraction)
  9. Nephrogenic anaemia (anaemia due to kidney disease)
  10. Osteopenia (a condition where bone mineral density is lower than normal)

male:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Tooth loss
  4. Blood creatinine increased
  5. Emotional distress
  6. Osteopenia (a condition where bone mineral density is lower than normal)
  7. Pain
  8. Renal disorder (kidney disease)
  9. Renal failure (kidney dysfunction)
  10. Blood glucose increased

What are the common drug interactions of Sps and Vitamin D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Hospitalisation

30-39:

n/a

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Chronic kidney disease
  4. Depression
  5. Diarrhoea
  6. Emotional distress
  7. Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
  8. Muscle spasms (muscle contraction)
  9. Nephrogenic anaemia (anaemia due to kidney disease)
  10. Osteopenia (a condition where bone mineral density is lower than normal)

50-59:

n/a

60+:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Anticoagulation drug level below therapeutic
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Blood glucose increased
  6. Breast cancer female
  7. Cardiac disorder
  8. Dysgeusia (disorder of the sense of taste)
  9. Fatigue (feeling of tiredness)
  10. Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

  1. Hyperkalemia (damage to or disease of the kidney): 5 people, 33.33%
  2. Hiv Infection: 5 people, 33.33%
  3. High Blood Pressure: 3 people, 20.00%
  4. Hepatitis C: 3 people, 20.00%
  5. Diabetes: 3 people, 20.00%
  6. Pain: 1 person, 6.67%
  7. Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 1 person, 6.67%
  8. Multiple Myeloma (cancer of the plasma cells): 1 person, 6.67%
  9. Breast Cancer Female: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Sps and Vitamin d?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sps and Vitamin d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sps:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Vitamin d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sps and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vitamin d and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on sodium polystyrene sulfonate and ergocalciferol (the active ingredients of Sps and Vitamin d, respectively), and Sps and Vitamin d (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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