Suboxone and Gravol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Gravol (dimenhydrinate). Common drug interactions include drug withdrawal syndrome neonatal among females and colitis among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Gravol. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Gravol?

Gravol has active ingredients of dimenhydrinate. It is often used in nausea. eHealthMe is studying from 7,192 Gravol users. Check the latest studies of Gravol.

On Jul, 28, 2026

30 people who take Suboxone and Gravol together, and have interactions are studied.

What are the common drug interactions of Suboxone and Gravol, by gender? *:

female:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Fall
Premature separation of placenta
Maternal exposure during pregnancy (use of substance during pregnancy)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Abdominal pain
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Abdominal discomfort
Constipation
Dehydration (dryness resulting from the removal of water)

male:

Colitis (inflammation of colon)
Fatigue (feeling of tiredness)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Mood swings (an extreme or rapid change in mood)
Overdose
Pain
Aggression
Anxiety
Cholangitis (infection of the bile duct)
Completed suicide (act of taking one's own life)

What are the common drug interactions of Suboxone and Gravol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Diarrhoea
Frequent bowel movements
General physical health deterioration (weak health status)
Haematochezia (passage of stools containing blood)
Pancreatic enzymes increased

20-29:

Abdominal discomfort
Abdominal pain
Constipation
Dehydration (dryness resulting from the removal of water)
Irritability
Mood swings (an extreme or rapid change in mood)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Renal pain (kidney pain)
Axillary mass
Cystitis (inflammation of the wall of the bladder)

30-39:

Haemoglobin decreased
Abdominal pain upper
Anaemia (lack of blood)
Bacterial test positive
Blood urine present
Crying
Emotional disorder
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)

40-49:

Fatigue (feeling of tiredness)
Pain
Cholangitis (infection of the bile duct)
Colitis (inflammation of colon)

50-59:

Aggression
Anxiety
Completed suicide (act of taking one's own life)
Depression
Disturbance in attention
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Mood swings (an extreme or rapid change in mood)
Overdose

60+:

n/a

What are the existing conditions these people have? *

Stress And Anxiety: 11 people, 36.67%
Morning Sickness (sickness in morning during pregnancy): 11 people, 36.67%
Drug Dependence: 10 people, 33.33%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 5 people, 16.67%
Migraine (headache): 3 people, 10.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 6.67%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 6.67%
Joint Pain: 2 people, 6.67%
Colon Cancer: 2 people, 6.67%
Back Pain: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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