Suboxone and Levothroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Levothroid (levothyroxine sodium). Common drug interactions include blood urea decreased among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Levothroid. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

On Jul, 21, 2026

11 people who take Suboxone and Levothroid together, and have interactions are studied.

Suboxone and Levothroid drug interactions.

What are the common drug interactions of Suboxone and Levothroid, by gender? *:

female:

Blood urea decreased
Constipation
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gardnerella test positive
Hallucination, visual (seeing things that aren't there)
Joint swelling
Mean cell volume decreased (less of the average red blood cell volume)
Nausea (feeling of having an urge to vomit)
Ovarian cyst (fluid filled sac of the ovary)
Drug hypersensitivity

male:

Aggression
Agitation (state of anxiety or nervous excitement)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Sleep talking (talking during sleeping)
Somnambulism (sleep walking)

What are the common drug interactions of Suboxone and Levothroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anion gap decreased
Basophil percentage decreased
Blood sodium decreased
Blood urea decreased
Gardnerella test positive
Mean cell volume decreased (less of the average red blood cell volume)
Nausea (feeling of having an urge to vomit)
Ovarian cyst (fluid filled sac of the ovary)
Drug exposure before pregnancy
Maternal exposure before pregnancy (use of substance before pregnancy)

30-39:

Chest pain
Muscle spasms (muscle contraction)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Oedema peripheral (superficial swelling)
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)
Painful respiration

40-49:

Tremor (trembling or shaking movements in one or more parts of your body)
Aggression
Agitation (state of anxiety or nervous excitement)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Sleep talking (talking during sleeping)
Somnambulism (sleep walking)
Constipation
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hallucination, visual (seeing things that aren't there)

50-59:

Drug hypersensitivity
Swelling
Swelling face
Visual impairment
Palpitations (feelings or sensations that your heart is pounding or racing)
Tremor (trembling or shaking movements in one or more parts of your body)

60+:

n/a

What are the existing conditions these people have? *

Pain: 4 people, 36.36%
Muscle Spasms (muscle contraction): 4 people, 36.36%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 36.36%
Depression: 3 people, 27.27%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 18.18%
Stress And Anxiety: 2 people, 18.18%
Sleep Disorder: 2 people, 18.18%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 2 people, 18.18%
Migraine (headache): 2 people, 18.18%
Dyspnea (difficult or laboured breathing): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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