Suboxone and Methylphenidate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Methylphenidate (methylphenidate). Common drug interactions include abnormal behaviour among females and respiratory depression among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Methylphenidate. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

On Jul, 09, 2026

31 people who take Suboxone and Methylphenidate together, and have interactions are studied.

Suboxone and Methylphenidate drug interactions.

What are the common drug interactions of Suboxone and Methylphenidate, by gender? *:

female:

Abnormal behaviour
Disturbance in attention
Hallucination (an experience involving the perception of something not present)
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Pain in extremity
Skin ulcer
Arthralgia (joint pain)
Bladder hypertrophy (bladder overgrowth- increase in cell size)
Cough
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

male:

Respiratory depression (respiration has a rate below 12 breaths)
Anxiety
Bone density decreased
Fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Renal failure (kidney dysfunction)
Thermal burn (burn by heat)
Tooth loss
Acute myocardial infarction (acute heart attack)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Suboxone and Methylphenidate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Agitation (state of anxiety or nervous excitement)
Anxiety
Asthenia (weakness)
Blood pressure increased
Confusional state
Decreased appetite
Depression
Disturbance in attention
Dizziness
Drug dependence

30-39:

n/a

40-49:

Chronic kidney disease

50-59:

Respiratory depression (respiration has a rate below 12 breaths)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hyperthermia (body temperature greatly above normal)
Pulmonary congestion (congestion in the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Abnormal behaviour
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Disturbance in attention

60+:

Acute myocardial infarction (acute heart attack)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Pain in extremity
Renal impairment (severely reduced kidney function)
Skin ulcer
Vomiting
Weight decreased
Chest pain
Dysarthria (speech disorder)
Pneumonia legionella (pneumonia caused by the bacteria legionella)

What are the existing conditions these people have? *

Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 13 people, 41.94%
Pain: 8 people, 25.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 19.35%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 19.35%
Hiv Infection: 4 people, 12.90%
Nausea (feeling of having an urge to vomit): 4 people, 12.90%
Drowsiness: 4 people, 12.90%
Depression: 3 people, 9.68%
Drug Dependence: 3 people, 9.68%
Stress And Anxiety: 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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