Suboxone and Mirapex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Mirapex (pramipexole dihydrochloride). Common drug interactions include hypertension among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Mirapex. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,250 Suboxone users. Check the latest studies of Suboxone.

What is Mirapex?

Mirapex has active ingredients of pramipexole dihydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 20,622 Mirapex users. Check the latest studies of Mirapex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

12 people who take Suboxone and Mirapex together, and have interactions are studied.

What are the common drug interactions of Suboxone and Mirapex, by gender? *:

female:

Hypertension (high blood pressure)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Surgery
Death
Depression
Drug level decreased
Pregnancy
Suicidal ideation

male:

Blood pressure increased
Bone pain
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Pain
Recurring skin boils
Tooth abscess (pus formation in tooth)
Toothache (tooth pain)
Urinary tract infection
Wheezing (a high-pitched whistling sound made while you breath)
Drug ineffective

What are the common drug interactions of Suboxone and Mirapex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug level decreased

20-29:

n/a

30-39:

Death

40-49:

Pain in extremity
Blood pressure increased
Bone pain
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Feeling of body temperature change
Insomnia (sleeplessness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

50-59:

Hypertension (high blood pressure)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Surgery

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 25.00%
Pain In Extremity: 2 people, 16.67%
Insomnia (sleeplessness): 2 people, 16.67%
Drug Dependence: 2 people, 16.67%
Depression: 2 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 8.33%
Hyperaesthesia: 1 person, 8.33%
Feeling Of Body Temperature Change: 1 person, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and Mirapex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously