Suboxone and Pentasa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Pentasa (mesalamine). Common drug interactions include abdominal pain among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Pentasa. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

On Jul, 19, 2026

13 people who take Suboxone and Pentasa together, and have interactions are studied.

What are the common drug interactions of Suboxone and Pentasa, by gender? *:

female:

Abdominal pain
Alopecia (absence of hair from areas of the body)
Anal fistula
Diarrhoea
Eating disorder
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Rectal abscess (pus in rectum)
Sinusitis (inflammation of sinus)

male:

Confusional state
Depressed level of consciousness
Depression
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fatigue (feeling of tiredness)
Hepatitis c
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Pain
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)

What are the common drug interactions of Suboxone and Pentasa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fatigue (feeling of tiredness)
Abdominal pain
Alopecia (absence of hair from areas of the body)
Anal fistula
Diarrhoea
Eating disorder
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Rectal abscess (pus in rectum)

40-49:

Hepatic failure (liver failure)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Psychotic disorder
Confusional state
Depressed level of consciousness
Drug level increased
Hallucination (an experience involving the perception of something not present)

50-59:

Facial bones fracture (bone fracture of face)
Fall
Skull fracture
Groin abscess (pus in groin)
Haematoma (collection of blood outside the blood vessels)
Osteomyelitis (infection of bone)
Surgery

60+:

n/a

What are the existing conditions these people have? *

Drug Dependence: 3 people, 23.08%
Diarrhea: 3 people, 23.08%
Dermatitis Exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss): 2 people, 15.38%
Stress And Anxiety: 1 person, 7.69%
Pain: 1 person, 7.69%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 7.69%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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