Suboxone and Propofol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Propofol (propofol). Common drug interactions include rash among females and bradycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Propofol. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Propofol?

Propofol has active ingredients of propofol. It is often used in colonoscopy abnormal. eHealthMe is studying from 38,224 Propofol users. Check the latest studies of Propofol.

On Jul, 07, 2026

36 people who take Suboxone and Propofol together, and have interactions are studied.

Suboxone and Propofol drug interactions.

What are the common drug interactions of Suboxone and Propofol, by gender? *:

female:

Rash
Respiratory rate decreased (less breathing rate/min)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Unresponsive to stimuli
Wheezing (a high-pitched whistling sound made while you breath)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Cardiac disorder
Cold sweat
Coronary artery bypass
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

male:

Bradycardia (abnormally slow heart action)
Cytokine storm (over-protective immune response that can actually be fatal)
Pneumonia
Retroperitoneal haematoma (blood clot between the peritoneum and the posterior abdominal wall)
Septic shock (shock due to blood infection)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Swelling
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Suboxone and Propofol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Thirst
Anxiety
Asthenia (weakness)
Depression
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Enterobacter sepsis (sepsis due to bacteria of the family enterobacteriaceae)
Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Intestinal infarction (intestinal tissue death)

20-29:

n/a

30-39:

Cardiac arrest
Arrhythmia (irregular heartbeat)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Brain death
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspnoea (difficult or laboured respiration)
Eye pruritus (eye itching)

40-49:

Anaesthetic complication
Pathological fracture (broken bone caused by disease)
Spinal cord compression

50-59:

Bradycardia (abnormally slow heart action)
Cytokine storm (over-protective immune response that can actually be fatal)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Haemoglobin decreased
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)
Hypotension (abnormally low blood pressure)
Iron deficiency
Lactic acidosis (low ph in body tissues)
Liver injury

60+:

Weight increased
Colitis ulcerative (inflammation of colon with ulcer)
Dizziness
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Genital disorder female (diseases of female genital tract)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Neoplasm (tumour)
Ovarian epithelial cancer (cancer that begins in the cells on the surface of the ovary)

What are the existing conditions these people have? *

Drug Dependence: 6 people, 16.67%
Urination - Excessive Volume: 4 people, 11.11%
Sleep Apnea Syndrome: 4 people, 11.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 11.11%
Drowsiness: 4 people, 11.11%
Sleep Disorder: 3 people, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 8.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 5.56%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 5.56%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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