Suboxone and Sulfamethoxazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Sulfamethoxazole (sulfamethoxazole). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Sulfamethoxazole. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Sulfamethoxazole?

Sulfamethoxazole has active ingredients of sulfamethoxazole. It is often used in urinary tract infection. eHealthMe is studying from 13,360 Sulfamethoxazole users. Check the latest studies of Sulfamethoxazole.

On Jul, 15, 2026

29 people who take Suboxone and Sulfamethoxazole together, and have interactions are studied.

Suboxone and Sulfamethoxazole drug interactions.

What are the common drug interactions of Suboxone and Sulfamethoxazole, by gender? *:

female:

Chronic kidney disease
Emotional distress
Drug hypersensitivity
Renal failure (kidney dysfunction)
Disability
Drug dependence
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Depression

male:

Chronic kidney disease
Renal injury (kidney injury)
Drug intolerance (drug sensitivity)
Eating disorder
Mastication disorder (disease of chewing food)
Muscle spasms (muscle contraction)
Obesity (having too much body fat)
Osteopenia (a condition where bone mineral density is lower than normal)
Overdose
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Suboxone and Sulfamethoxazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug dependence
Overdose

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

40-49:

Chronic kidney disease
Renal injury (kidney injury)
Abdominal pain upper
Abnormal dreams
Back pain
Cough
Death
Diarrhoea
Duodenitis (inflammation of the duodenum)
Dysuria (painful or difficult urination)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pain
Renal failure (kidney dysfunction)
Tooth loss
Upper limb fracture
Anxiety
Bone density decreased
Depression
Emotional distress
Fracture

60+:

Drug hypersensitivity

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 41.38%
Hiv Infection: 10 people, 34.48%
Pain: 9 people, 31.03%
Infection: 8 people, 27.59%
High Blood Pressure: 5 people, 17.24%
Blood Pressure Abnormal: 3 people, 10.34%
Post-Traumatic Stress Disorder: 2 people, 6.90%
Oedema (fluid collection in tissue): 2 people, 6.90%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.90%
Muscle Spasms (muscle contraction): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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