Suboxone and Tagamet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) and Tagamet (cimetidine). Common drug interactions include hospitalisation among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Suboxone and Tagamet. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Tagamet?

Tagamet has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,011 Tagamet users. Check the latest studies of Tagamet.

On Aug, 08, 2026

14 people who take Suboxone and Tagamet together, and have interactions are studied.

What are the common drug interactions of Suboxone and Tagamet, by gender? *:

female:

Hospitalisation
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Speech disorder
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Renal impairment (severely reduced kidney function)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Lactic acidosis (low ph in body tissues)
Malaise (a feeling of general discomfort or uneasiness)
Mouth ulceration (mouth ulcers)
Drug ineffective

male:

Chronic kidney disease
Glossodynia (a burning or painful sensation in the tongue)
Renal injury (kidney injury)
Swollen tongue (swelling of tongue)

What are the common drug interactions of Suboxone and Tagamet, by age (0-1 to 60+)? *:

0-1:

Glossodynia (a burning or painful sensation in the tongue)
Swollen tongue (swelling of tongue)

2-9:

n/a

10-19:

n/a

20-29:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Lactic acidosis (low ph in body tissues)
Malaise (a feeling of general discomfort or uneasiness)
Mouth ulceration (mouth ulcers)
Drug ineffective
Hospitalisation

30-39:

Chronic kidney disease

40-49:

Chronic kidney disease
Renal injury (kidney injury)

50-59:

n/a

60+:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Lactic acidosis (low ph in body tissues)
Malaise (a feeling of general discomfort or uneasiness)
Mouth ulceration (mouth ulcers)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Speech disorder
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)

What are the existing conditions these people have? *

Joint Pain: 8 people, 57.14%
Neuralgia (pain in one or more nerves): 7 people, 50.00%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 7 people, 50.00%
Pain: 6 people, 42.86%
Depression: 5 people, 35.71%
Post-Traumatic Stress Disorder: 5 people, 35.71%
High Blood Pressure: 5 people, 35.71%
Infection: 5 people, 35.71%
Urinary Tract Disorder: 4 people, 28.57%
Blood Potassium Decreased: 4 people, 28.57%

* Approximation only. Some reports may have incomplete information.

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