Subsys and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Subsys (fentanyl) and Ibu (ibuprofen). Common drug interactions include drug withdrawal syndrome among females and overdose among males.

The phase IV clinical study analyzes what interactions people have when they take Subsys and Ibu. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Subsys?

Subsys has active ingredients of fentanyl. eHealthMe is studying from 9,239 Subsys users. Check the latest studies of Subsys.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

On Jul, 27, 2026

14 people who take Subsys and Ibu together, and have interactions are studied.

What are the common drug interactions of Subsys and Ibu, by gender? *:

female:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Chronic kidney disease
Renal failure (kidney dysfunction)
Euphoric mood (excessively happy but may become angry or irritable)
Suicidal ideation
Cold sweat
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Feeling hot
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

male:

Overdose
Unresponsive to stimuli
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Metastases to bone (cancer spreads to bone)
Metastases to liver (cancer spreads to liver)
Neoplasm progression (growth of tumour)
Stress
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Abdominal pain upper

What are the common drug interactions of Subsys and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Urinary tract infection
Vomiting
White blood cell count decreased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Thrombosis (formation of a blood clot inside a blood vessel)

50-59:

Overdose
Unresponsive to stimuli

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Breakthrough Pain: 7 people, 50.00%
Headache (pain in head): 3 people, 21.43%
Multiple Myeloma (cancer of the plasma cells): 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Constipation: 1 person, 7.14%
Fever: 1 person, 7.14%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 7.14%
Drug Level Increased: 1 person, 7.14%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 1 person, 7.14%
Depression: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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