Subutex and Amoxicillin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Subutex (buprenorphine hydrochloride) and Amoxicillin (amoxicillin). Common drug interactions include diarrhoea among females and overdose among males.

The phase IV clinical study analyzes what interactions people have when they take Subutex and Amoxicillin. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,763 Subutex users. Check the latest studies of Subutex.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

35 people who take Subutex and Amoxicillin together, and have interactions are studied.

Subutex and Amoxicillin drug interactions.

What are the common drug interactions of Subutex and Amoxicillin, by gender? *:

female:

Diarrhoea
Dizziness
Hallucination, olfactory (sensations of smelling something that is actually not there)
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)
Vomiting
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Drug exposure during pregnancy
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)

male:

Overdose
Coma (state of unconsciousness lasting more than six hours)
Dyspnoea (difficult or laboured respiration)
Endocarditis bacterial (an inflammation of the inner layer of the heart by bacterial infection)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Hyperhidrosis (abnormally increased sweating)
Hypertonia neonatal (abnormal increase in muscle tension and a reduced ability of a muscle to stretch in neonatal)
Localised infection (infection at the single location)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Meningitis bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)

What are the common drug interactions of Subutex and Amoxicillin, by age (0-1 to 60+)? *:

0-1:

Agitation neonatal (people with depression, obsessive-compulsive disorder, post viral fatigue syndrome, schizophrenia, bipolar i disorder)
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Hypertonia neonatal (abnormal increase in muscle tension and a reduced ability of a muscle to stretch in neonatal)
Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)

2-9:

n/a

10-19:

n/a

20-29:

Overdose
Coma (state of unconsciousness lasting more than six hours)
Substance abuse
Dyspnoea (difficult or laboured respiration)
Hyperhidrosis (abnormally increased sweating)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anxiety
Arthralgia (joint pain)
Drug dependence
Insomnia (sleeplessness)

30-39:

Drug exposure during pregnancy
Bk virus infection
Hepatitis (inflammation of the liver)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Viral haemorrhagic cystitis (lower urinary tract symptoms that include haematuria and irritative voiding symptoms)
Premature delivery
Premature labour
Purpura (purplish discoloration of the skin)
Pyrexia (fever)
Rash pustular (redness with pustules)

40-49:

Anaemia (lack of blood)
Aortic valve incompetence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Endocarditis bacterial (an inflammation of the inner layer of the heart by bacterial infection)
Glomerular filtration rate decreased
Localised infection (infection at the single location)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Meningitis bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Oedema (fluid collection in tissue)
Oesophageal stenosis (narrowing of oesophagus)

50-59:

Diarrhoea
Dizziness
Hallucination, olfactory (sensations of smelling something that is actually not there)
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)
Vomiting
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Drug administration error

60+:

Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Drug Dependence: 9 people, 25.71%
Depression: 6 people, 17.14%
Urinary Tract Infection: 3 people, 8.57%
Pain: 3 people, 8.57%
Asthma: 3 people, 8.57%
Thrombophlebitis Superficial (swelling (inflammation) of a superficial vein caused by a blood clot): 2 people, 5.71%
Oral Candidiasis (fungal infection of mouth): 2 people, 5.71%
Insomnia (sleeplessness): 2 people, 5.71%
Helicobacter Gastritis (inflammation of the inner lining of the stomach caused by helicobacter pylori (h. pylori) a bacterium): 2 people, 5.71%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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