Subutex and Paxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Subutex (buprenorphine hydrochloride) and Paxil (paroxetine hydrochloride). Common drug interactions include speech disorder among females and premature baby among males.

The phase IV clinical study analyzes what interactions people have when they take Subutex and Paxil. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,763 Subutex users. Check the latest studies of Subutex.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

On Jul, 13, 2026

74 people who take Subutex and Paxil together, and have interactions are studied.

What are the common drug interactions of Subutex and Paxil, by gender? *:

female:

Speech disorder
Stomach discomfort (pain in abdomen)
Swelling
Tremor (trembling or shaking movements in one or more parts of your body)
Ulcer
Victim of crime
Visual acuity reduced (reduced clearness of vision)
Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug abuse

male:

Premature baby
Low birth weight baby
Dizziness
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Joint stiffness
Paralysis
Abnormal palmar/plantar creases (normal groove across the palm of the hand)
Apgar score low
Apnoea (suspension of external breathing)
Blood culture positive

What are the common drug interactions of Subutex and Paxil, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Low birth weight baby
Premature baby
Tremor neonatal (excited neuromuscular activity of newborns)

2-9:

n/a

10-19:

n/a

20-29:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Dizziness
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Joint stiffness
Paralysis
Alcohol poisoning
Decreased appetite
Diarrhoea
Drug dependence
Drug exposure during pregnancy

30-39:

Drug abuse
Drug screen positive
Intentional self-injury
Overdose
Pelvic pain
Suicidal ideation
Non-alcoholic steatohepatitis (liver inflammation caused by a build up of fat in the liver)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Altered state of consciousness (altered state of mind)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)

40-49:

Weight increased
Depersonalisation
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Eye swelling
Fatigue (feeling of tiredness)
Hypersensitivity
Swelling

50-59:

n/a

60+:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Feeling hot
Flushing (the warm, red condition of human skin)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

What are the existing conditions these people have? *

Drug Dependence: 40 people, 54.05%
Stress And Anxiety: 24 people, 32.43%
Birth Control: 13 people, 17.57%
Quit Smoking: 6 people, 8.11%

* Approximation only. Some reports may have incomplete information.

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