Sudafed and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include jugular vein distension among females and haematuria present among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Tylenol w/ codeine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

On Jul, 18, 2026

22 people who take Sudafed and Tylenol w/ codeine together, and have interactions are studied.

Sudafed and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Sudafed and Tylenol W/ Codeine, by gender? *:

female:

Jugular vein distension (overloaded jugular vein)
Chest pain
Nervousness
Palpitations (feelings or sensations that your heart is pounding or racing)
Arthralgia (joint pain)
Abdominal pain upper
Bipolar disorder (mood disorder)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chills (felling of cold)
Heart rate increased

male:

Haematuria present (presence of blood in urine due to trauma)
International normalised ratio increased
Vomiting
Abnormal behaviour
Death
Unresponsive to stimuli
Aggression
Arrhythmia (irregular heartbeat)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Psychotic behaviour

What are the common drug interactions of Sudafed and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Arrhythmia (irregular heartbeat)
Sudden death
Unresponsive to stimuli
Vomiting

10-19:

Abnormal behaviour

20-29:

Abdominal pain upper
Bipolar disorder (mood disorder)
Chest pain
Chills (felling of cold)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Migraine (headache)
Nausea (feeling of having an urge to vomit)

30-39:

Haematuria present (presence of blood in urine due to trauma)
International normalised ratio increased
Anaemia (lack of blood)
Cardiomyopathy (weakening of the heart muscle)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Drug exposure during pregnancy
Syncope (loss of consciousness with an inability to maintain postural tone)
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)

40-49:

Pruritus (severe itching of the skin)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Abnormal dreams
Arthralgia (joint pain)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Muscle spasms (muscle contraction)
Chest discomfort
Drug ineffective
Injection site erythema (redness at injection site)

50-59:

Death

60+:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Agitation (state of anxiety or nervous excitement)
Blood alkaline phosphatase increased
Blood bilirubin increased
Bone infarction (ischemic death of the cellular elements of the bone and marrow)
Brain natriuretic peptide increased
Breath sounds absent
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)

What are the existing conditions these people have? *

Quit Smoking: 3 people, 13.64%
Panic Disorder: 2 people, 9.09%
Migraine (headache): 2 people, 9.09%
Iron Overload: 2 people, 9.09%
Headache (pain in head): 2 people, 9.09%
Bipolar Disorder (mood disorder): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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