Sudafed and Vesicare drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Vesicare (solifenacin succinate). Common drug interactions include depression among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Vesicare. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Vesicare?

Vesicare has active ingredients of solifenacin succinate. It is often used in urge incontinence. eHealthMe is studying from 30,656 Vesicare users. Check the latest studies of Vesicare.

On Jul, 10, 2026

47 people who take Sudafed and Vesicare together, and have interactions are studied.

What are the common drug interactions of Sudafed and Vesicare, by gender? *:

female:

Depression
Diplopia (double vision)
Dyspepsia (indigestion)
Emotional distress
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Fungal skin infection
Haematoma (collection of blood outside the blood vessels)
Hypoacusis (loss of hearing)
Impaired driving ability

male:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Liver abscess (pus in liver)
Pneumonia
Psychotic disorder
Vomiting
Weight decreased
White blood cell count increased
Decreased activity

What are the common drug interactions of Sudafed and Vesicare, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Attention deficit/hyperactivity disorder
Dizziness
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Incision site pain
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Paresis anal sphincter (a condition of muscular weakness of anal sphincter)
Postoperative wound infection
Rectal polyp (fleshy growth occurring on the lining of the colon)
Rectal prolapse (falling of rectum from normal place)
Tremor (trembling or shaking movements in one or more parts of your body)

40-49:

Diarrhoea
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diplopia (double vision)
Ear infection
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Impaired driving ability
Impaired work ability
Photophobia (extreme sensitivity to light)

50-59:

Pruritus generalised (generalized itching)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Headache (pain in head)
Injection site erythema (redness at injection site)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Cough
Diarrhoea
Drug hypersensitivity

60+:

Fatigue (feeling of tiredness)
Dysgeusia (disorder of the sense of taste)
Drug ineffective
Dry mouth
Facial bones fracture (bone fracture of face)
Liver abscess (pus in liver)
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Psychotic disorder
Tobacco user

What are the existing conditions these people have? *

Urinary Incontinence (inability to control the flow of urine and involuntary urination): 8 people, 17.02%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 12.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 12.77%
Parkinson's Disease: 5 people, 10.64%
Muscle Spasms (muscle contraction): 5 people, 10.64%
Immunodeficiency Common Variable: 5 people, 10.64%
Seasonal Allergy (allergic condition due to certain season): 4 people, 8.51%
Pain: 4 people, 8.51%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.51%
Automatic Bladder (nerve impulses between the bladder and the spinal cord remain intact and the bladder can be trained to empty by reflex (spastic) action): 4 people, 8.51%

* Approximation only. Some reports may have incomplete information.

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