Sumatriptan and Esgic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sumatriptan (sumatriptan succinate) and Esgic (acetaminophen; butalbital; caffeine). Common drug interactions include dehydration among females and angioneurotic oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Sumatriptan and Esgic. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

On Jul, 13, 2026

13 people who take Sumatriptan and Esgic together, and have interactions are studied.

Sumatriptan and Esgic drug interactions.

What are the common drug interactions of Sumatriptan and Esgic, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypersensitivity
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Nausea (feeling of having an urge to vomit)
Oral pain
Stomatitis (inflammation of mucous membrane of mouth)
Asthenia (weakness)

male:

Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Hepatic enzyme increased
Liver transplant
Pruritus (severe itching of the skin)
Renal transplant
Sepsis (a severe blood infection that can lead to organ failure and death)
Transplant rejection (a transplant material is not worked)

What are the common drug interactions of Sumatriptan and Esgic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Abdominal pain
Abdominal pain lower
Anuria (failure of the kidneys to produce urine)
Constipation
Diarrhoea
Drug ineffective
Gastrointestinal motility disorder (abnormal intestinal contractions)
Haemoglobin decreased
Megacolon (a very dilated colon)

30-39:

Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Pruritus (severe itching of the skin)

40-49:

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Oropharyngeal pain
Throat irritation

50-59:

Asthenia (weakness)
Drug ineffective
Foot fracture
Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response unexpected
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Injection site urticaria (rash of round, red welts on the skin at injection site)
Nausea (feeling of having an urge to vomit)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 23.08%
Headache (pain in head): 3 people, 23.08%
Sleep Disorder: 2 people, 15.38%
Breast Cancer: 2 people, 15.38%
Pain: 2 people, 15.38%
Stress And Anxiety: 2 people, 15.38%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 7.69%
High Blood Cholesterol: 1 person, 7.69%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 7.69%
Cystic Fibrosis (disease of the secretary glands): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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