Sunitinib malate and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sunitinib malate (sunitinib malate) and Spironolactone (spironolactone). Common drug interactions include disease progression among females and ascites among males.

The phase IV clinical study analyzes what interactions people have when they take Sunitinib malate and Spironolactone. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Sunitinib malate?

Sunitinib malate has active ingredients of sunitinib malate. eHealthMe is studying from 9,160 Sunitinib malate users. Check the latest studies of Sunitinib malate.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

85 people who take Sunitinib malate and Spironolactone together, and have interactions are studied.

Sunitinib malate and Spironolactone drug interactions.

What are the common drug interactions of Sunitinib Malate and Spironolactone, by gender? *:

female:

Disease progression
Nausea (feeling of having an urge to vomit)
Vomiting
Acute myocardial infarction (acute heart attack)
Cardiac arrest
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Gastrointestinal stromal tumour (a cancer that arises from transformed cells of mesenchymal origin in gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

male:

Ascites (accumulation of fluid in the abdominal cavity)
Dehydration (dryness resulting from the removal of water)
Vomiting
Death
Depression
Dyspnoea (difficult or laboured respiration)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nausea (feeling of having an urge to vomit)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Sunitinib Malate and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death
Hypotension (abnormally low blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neutropenia (an abnormally low number of neutrophils)
Pulmonary thrombosis (scarring in the lungs)
Atrioventricular block (heart block)
Chest pain
Hypoxia (low oxygen in tissues)
Pericardial effusion (fluid around the heart)
Platelet count decreased

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Disease progression
Anaemia (lack of blood)
Constipation
Depression
Fatigue (feeling of tiredness)
Gastrointestinal stromal tumour (a cancer that arises from transformed cells of mesenchymal origin in gastrointestinal tract)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Neutropenia (an abnormally low number of neutrophils)
Blood potassium decreased

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Confusional state
Disease progression
Dyspnoea (difficult or laboured respiration)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Renal cell carcinoma (a kidney cancer)
Dehydration (dryness resulting from the removal of water)
Anuria (failure of the kidneys to produce urine)

60+:

Dehydration (dryness resulting from the removal of water)
Disease progression
Leukopenia (less number of white blood cells in blood)
Nausea (feeling of having an urge to vomit)
Renal impairment (severely reduced kidney function)
Bronchial obstruction (blockage of the breathing passages to the lungs)
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Hepatic Neoplasm Malignant (liver cancer): 32 people, 37.65%
Renal Cell Carcinoma (a kidney cancer): 11 people, 12.94%
Gastrointestinal Stromal Tumor: 11 people, 12.94%
Pain: 10 people, 11.76%
Constipation: 10 people, 11.76%
High Blood Pressure: 9 people, 10.59%
Gastritis (inflammation of stomach): 8 people, 9.41%
Diabetes: 8 people, 9.41%
Liver Disorder (liver diseases): 7 people, 8.24%
Ascites (accumulation of fluid in the abdominal cavity): 7 people, 8.24%

* Approximation only. Some reports may have incomplete information.

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