Symmetrel and Celexa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Symmetrel (amantadine hydrochloride) and Celexa (citalopram hydrobromide). Common drug interactions include chorea among females and collapse among males.

The phase IV clinical study analyzes what interactions people have when they take Symmetrel and Celexa. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Symmetrel?

Symmetrel has active ingredients of amantadine hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,398 Symmetrel users. Check the latest studies of Symmetrel.

What is Celexa?

Celexa has active ingredients of citalopram hydrobromide. It is often used in depression. eHealthMe is studying from 56,390 Celexa users. Check the latest studies of Celexa.

On Aug, 09, 2026

56 people who take Symmetrel and Celexa together, and have interactions are studied.

What are the common drug interactions of Symmetrel and Celexa, by gender? *:

female:

Chorea (abnormal involuntary movement disorder)
Confusion
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Cough
Crush injury (compression of extremities or other parts of the body that causes muscle swelling and/or neurological disturbances)
Csf glucose decreased
Csf white blood cell count increased
Deafness
Delirium (wild excitement)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

male:

Collapse (sudden functional breakdown)
Dehydration (dryness resulting from the removal of water)
Fall
Feeling hot
Hallucination (an experience involving the perception of something not present)
Hyperpyrexia (extremely high fever)
Hypersomnia (excessive daytime sleepiness (eds))
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Symmetrel and Celexa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Collapse (sudden functional breakdown)
Heat stroke
Abdominal pain
Abdominal pain lower
Accidental exposure
Acute sinusitis
Alcohol abuse
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cervicitis (inflammation of the uterine cervix)

30-39:

Hypertension (high blood pressure)
Obesity (having too much body fat)
Hepatitis c
Insomnia (sleeplessness)
Cholecystitis (infection of gallbladder)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Anaemia (lack of blood)
Diabetes mellitus non-insulin-dependent
Platelet count decreased
Asthenia (weakness)

40-49:

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Abdominal pain
Accident
Adverse drug reaction
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Deafness
Decreased appetite

50-59:

Hepatic steatosis (fatty liver disease)
Weight increased
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Serum ferritin decreased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Gamma-glutamyltransferase increased
Disease progression
Progressive multiple sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord)

60+:

Fall
Foot fracture
Meningitis cryptococcal (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Neurotransmitter level altered
Pleocytosis (increased cell count)
Pleural effusion (water on the lungs)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Road traffic accident
Transient global amnesia (a temporary short-term memory loss)
Urinary tract infection

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 25 people, 44.64%
Pain: 9 people, 16.07%
Bipolar Disorder (mood disorder): 6 people, 10.71%
Gait Disturbance: 5 people, 8.93%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 7.14%
High Blood Pressure: 4 people, 7.14%
Drowsiness: 4 people, 7.14%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 3 people, 5.36%
Insomnia (sleeplessness): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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