Symmetrel and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Symmetrel (amantadine hydrochloride) and Wellbutrin (bupropion hydrochloride). Common drug interactions include back pain among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Symmetrel and Wellbutrin. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Symmetrel?

Symmetrel has active ingredients of amantadine hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,398 Symmetrel users. Check the latest studies of Symmetrel.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

On Jul, 14, 2026

34 people who take Symmetrel and Wellbutrin together, and have interactions are studied.

Symmetrel and Wellbutrin drug interactions.

What are the common drug interactions of Symmetrel and Wellbutrin, by gender? *:

female:

Back pain
Bacteraemia (presence of bacteria in the blood)
Blood creatine phosphokinase increased
Blood glucose fluctuation
Blood lactate dehydrogenase increased
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Cerebral atrophy (decrement in size of brain)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Adjustment disorder
Agitation (state of anxiety or nervous excitement)
Bacteraemia (presence of bacteria in the blood)
Blood creatine phosphokinase increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cataract (clouding of the lens inside the eye)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Symmetrel and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Corneal oedema (corneal swelling)

20-29:

Aggression
Coma (state of unconsciousness lasting more than six hours)
Confusion
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fall
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate increased
Memory impairment

30-39:

n/a

40-49:

Appendicitis (inflammation of the appendix)
Cholecystitis (infection of gallbladder)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Injection site reaction
Livedo reticularis (a lace-like purplish discoloration of the skin)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Urinary tract infection
Adjustment disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive

50-59:

Skin discomfort (skin pain/irritation)
Skin exfoliation (removal of the oldest dead skin cells)
Skin lesion
Skin wound
Small cell lung cancer metastatic (lung cancer spreads to other body parts)
Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop)
Hepatic steatosis (fatty liver disease)
Weight increased
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Serum ferritin decreased

60+:

Bacteraemia (presence of bacteria in the blood)
Blood creatine phosphokinase increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aortic arteriosclerosis (hardening of the aortic arteries)
Asthenia (weakness)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Blood glucose fluctuation
Cardiac failure congestive
Cerebral atrophy (decrement in size of brain)
Cerebral ventricle dilatation (enlargement of ventricle of brain)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 14 people, 41.18%
Prostatomegaly (enlargement of the prostate): 3 people, 8.82%
Nausea (feeling of having an urge to vomit): 3 people, 8.82%
Kidney Stones: 3 people, 8.82%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 2 people, 5.88%
Pain: 2 people, 5.88%
Flatulence (flatus expelled through the anus): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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