Symproic and Belsomra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Symproic (naldemedine tosylate) and Belsomra (suvorexant). Common drug interactions include weight decreased among females and delirium among males.

The phase IV clinical study analyzes what interactions people have when they take Symproic and Belsomra. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Symproic?

Symproic has active ingredients of naldemedine tosylate. eHealthMe is studying from 1,487 Symproic users. Check the latest studies of Symproic.

What is Belsomra?

Belsomra has active ingredients of suvorexant. It is often used in insomnia. eHealthMe is studying from 12,961 Belsomra users. Check the latest studies of Belsomra.

On Jul, 11, 2026

35 people who take Symproic and Belsomra together, and have interactions are studied.

Symproic and Belsomra drug interactions.

What are the common drug interactions of Symproic and Belsomra, by gender? *:

female:

Weight decreased
Gamma-glutamyltransferase increased
Delirium (wild excitement)
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood pressure decreased
Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick)
Left ventricle outflow tract obstruction
Pyrexia (fever)
Agitation (state of anxiety or nervous excitement)

male:

Delirium (wild excitement)
Diarrhoea
Malignant neoplasm progression (cancer tumour came back)
Pain
Platelet count decreased
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Somnolence (a state of near-sleep, a strong desire for sleep)
Cardiac failure
Decreased appetite
Disease progression

What are the common drug interactions of Symproic and Belsomra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Constipation
Delirium (wild excitement)
Mouth haemorrhage (bleeding from mouth)
Pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Nasopharyngitis (inflammation of the nasopharynx)
Pyrexia (fever)
Gastroenteritis (inflammation of stomach and intestine)
Liver disorder (liver diseases)
Malignant neoplasm progression (cancer tumour came back)

40-49:

Pyrexia (fever)
Delirium (wild excitement)
Interstitial lung disease
Lung disorder (lung disease)
Malignant neoplasm progression (cancer tumour came back)
Rash
Substance-induced psychotic disorder
Abdominal pain
Appendicitis (inflammation of the appendix)
Cardiac failure

50-59:

Pancreatic carcinoma (pancreatic cancer)
Platelet count decreased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypertension (high blood pressure)
Pancreatogenous diabetes
Pyrexia (fever)

60+:

Delirium (wild excitement)
Nausea (feeling of having an urge to vomit)
Left ventricle outflow tract obstruction
Diarrhoea
Hyperglycaemia (high blood sugar)
Mouth haemorrhage (bleeding from mouth)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Non-small cell lung cancer (type of epithelial lung cancer)
Osteonecrosis of jaw (death of bone of jaw)
Pneumonia bacterial (pneumonia associated with bacterial infection)

What are the existing conditions these people have? *

Constipation: 12 people, 34.29%
Cancer Pain: 9 people, 25.71%
Pain: 8 people, 22.86%
Metastases To Bone (cancer spreads to bone): 6 people, 17.14%
Stress And Anxiety: 5 people, 14.29%
Gastric Ulcer (stomach ulcer): 4 people, 11.43%
Blood Catecholamines Increased: 3 people, 8.57%
High Blood Pressure: 3 people, 8.57%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 3 people, 8.57%
Nausea (feeling of having an urge to vomit): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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