Symproic and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Symproic (naldemedine tosylate) and Linzess (linaclotide). Common drug interactions include hepatitis acute among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Symproic and Linzess. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Symproic?

Symproic has active ingredients of naldemedine tosylate. eHealthMe is studying from 1,487 Symproic users. Check the latest studies of Symproic.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

On Jul, 20, 2026

52 people who take Symproic and Linzess together, and have interactions are studied.

What are the common drug interactions of Symproic and Linzess, by gender? *:

female:

Hepatitis acute
Large intestinal ulcer haemorrhage (bleeding from large intestine ulcer)
Malaise (a feeling of general discomfort or uneasiness)
Mixed connective tissue disease (an autoimmune disease, in which the body's defence system attacks itself)
Monoplegia (a paralysis of a single limb)
Neoplasm progression (growth of tumour)
Neuropathy peripheral (surface nerve damage)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pain
Platelet count decreased

male:

Diarrhoea
Pyrexia (fever)
Cardiac failure congestive
Death
Mouth haemorrhage (bleeding from mouth)
Pain
Pruritus (severe itching of the skin)
Cardiac arrest
Anastomotic complication (complication of surgical connection between two structures)
Back pain

What are the common drug interactions of Symproic and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Altered state of consciousness (altered state of mind)
Delirium (wild excitement)
Diarrhoea
Mouth haemorrhage (bleeding from mouth)
Pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Nasopharyngitis (inflammation of the nasopharynx)
Pyrexia (fever)
Abdominal infection

40-49:

Cardiac failure
Colitis (inflammation of colon)
Dysphonia (speech disorder attributable to a disorder of phonation)
Enteritis infectious (infection with feline parvovirus (fpv), also known as feline panleucopenia virus)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Malaise (a feeling of general discomfort or uneasiness)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Pyrexia (fever)
Rash

50-59:

Cardiac arrest
Death
Ileus (a painful obstruction of the ileum or other part of the intestine)
Pyrexia (fever)
Adenocarcinoma pancreas (cancer of pancreas)
Muscular weakness (muscle weakness)
Dysphonia (speech disorder attributable to a disorder of phonation)
Gastrointestinal perforation (hole in the digestive tract)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Malignant neoplasm progression (cancer tumour came back)

60+:

Nausea (feeling of having an urge to vomit)
Hypertension (high blood pressure)
Delirium (wild excitement)
Pyrexia (fever)
Anastomotic complication (complication of surgical connection between two structures)
Back pain
Bone cancer metastatic
Cancer pain
Chest pain
Cystitis (inflammation of the wall of the bladder)

What are the existing conditions these people have? *

Cancer Pain: 9 people, 17.31%
Endometrial Cancer: 6 people, 11.54%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 9.62%
Blood Catecholamines Increased: 4 people, 7.69%
Thymoma (a tumour originating from the epithelial cells of the thymus): 3 people, 5.77%
Non-Small Cell Lung Cancer Recurrent (type of epithelial lung cancer reoccurrence): 3 people, 5.77%
Lung Cancer - Non-Small Cell (lung cancer): 3 people, 5.77%
High Blood Pressure: 3 people, 5.77%
Gastric Cancer (stomach cancer): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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