Synjardy and Morphine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synjardy (empagliflozin; metformin hydrochloride) and Morphine (morphine sulfate). Common drug interactions include acute pulmonary oedema among females and acne among males.

The phase IV clinical study analyzes what interactions people have when they take Synjardy and Morphine. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

On Jul, 30, 2026

16 people who take Synjardy and Morphine together, and have interactions are studied.

Synjardy and Morphine drug interactions.

What are the common drug interactions of Synjardy and Morphine, by gender? *:

female:

Acute pulmonary oedema (sudden deposit of fluid in the lung))
Blood lactic acid increased
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Respiratory failure (inadequate gas exchange by the respiratory system)
Respiratory tract infection
Vomiting

male:

Acne (skin problems that cause pimples)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Feeding disorder (when children refuse to eat certain food groups)
Mobility decreased (ability to move is reduced)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Nerve compression
Pain in jaw
Peripheral swelling
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

What are the common drug interactions of Synjardy and Morphine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Transaminases increased
Scrotal abscess (pus in scrotum)

50-59:

Constipation
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

60+:

Vomiting
Acne (skin problems that cause pimples)
Dyspnoea (difficult or laboured respiration)
Feeding disorder (when children refuse to eat certain food groups)
Mobility decreased (ability to move is reduced)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Nerve compression
Pain in jaw
Peripheral swelling
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

What are the existing conditions these people have? *

Diabetes: 8 people, 50.00%
Type 2 Diabetes: 5 people, 31.25%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 12.50%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 12.50%
Depression: 2 people, 12.50%
Weight Decreased: 1 person, 6.25%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 6.25%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 6.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Synjardy and Morphine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously