Synthroid and Doxylamine succinate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and Doxylamine succinate (doxylamine succinate). Common drug interactions include muscular weakness among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and Doxylamine succinate. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

What is Doxylamine succinate?

Doxylamine succinate has active ingredients of doxylamine succinate. It is often used in insomnia. eHealthMe is studying from 2,851 Doxylamine succinate users. Check the latest studies of Doxylamine succinate.

On Jul, 24, 2026

32 people who take Synthroid and Doxylamine succinate together, and have interactions are studied.

Synthroid and Doxylamine succinate drug interactions.

What are the common drug interactions of Synthroid and Doxylamine Succinate, by gender? *:

female:

Muscular weakness (muscle weakness)
Asthenia (weakness)
Conjunctivitis (pink eye)
Dehydration (dryness resulting from the removal of water)
Drug toxicity
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)
Pain in extremity
Weight increased

male:

Anxiety
Mitral valve disease (disease of mitral valve of heart)
Premature baby
Plasma cell myeloma (cancer that begins in plasma cells)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Synthroid and Doxylamine Succinate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abnormal behaviour
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Lethargy (tiredness)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Suicidal ideation

30-39:

Disease recurrence
Maternal exposure during pregnancy (use of substance during pregnancy)

40-49:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Fatigue (feeling of tiredness)
Decreased appetite
Diarrhoea
Foot fracture

50-59:

Drug toxicity
Anaemia (lack of blood)
Bone marrow failure
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Eyelid bleeding
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Lacrimation increased
Localised infection (infection at the single location)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Pain in extremity

What are the existing conditions these people have? *

Pain: 10 people, 31.25%
High Blood Pressure: 10 people, 31.25%
Migraine (headache): 6 people, 18.75%
Sleep Disorder: 5 people, 15.62%
Eclampsia (acute and life-threatening complication of pregnancy): 5 people, 15.62%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 15.62%
Stress And Anxiety: 4 people, 12.50%
Nausea (feeling of having an urge to vomit): 3 people, 9.38%
Muscle Spasms (muscle contraction): 3 people, 9.38%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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