Synthroid and Ellence drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and Ellence (epirubicin hydrochloride). Common drug interactions include alopecia among females.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and Ellence. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,202 Synthroid users. Check the latest studies of Synthroid.

What is Ellence?

Ellence has active ingredients of epirubicin hydrochloride. eHealthMe is studying from 943 Ellence users. Check the latest studies of Ellence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 15, 2026

25 people who take Synthroid and Ellence together, and have interactions are studied.

Synthroid and Ellence drug interactions.

What are the common drug interactions of Synthroid and Ellence, by gender? *:

female:

  1. Alopecia (absence of hair from areas of the body)
  2. Emotional distress
  3. Blood calcium decreased
  4. Blood creatinine increased
  5. Breath sounds
  6. Cardiomyopathy (weakening of the heart muscle)
  7. Diarrhoea
  8. Ejection fraction decreased (systolic heart failure)
  9. Haematocrit decreased
  10. Haemoglobin decreased

male:

n/a

What are the common drug interactions of Synthroid and Ellence, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Alopecia (absence of hair from areas of the body)
  2. Anxiety
  3. Emotional distress
  4. Pain

40-49:

  1. Alopecia (absence of hair from areas of the body)
  2. Psychological trauma
  3. Anxiety
  4. Emotional distress
  5. Hair colour changes
  6. Hair disorder
  7. Pain

50-59:

  1. Alopecia (absence of hair from areas of the body)
  2. Anxiety
  3. Emotional distress
  4. Febrile neutropenia (fever with reduced white blood cells)
  5. Hair colour changes
  6. Hair disorder
  7. Psychological trauma
  8. Abdominal pain
  9. Blood albumin decreased
  10. Blood calcium decreased

60+:

  1. Alopecia (absence of hair from areas of the body)
  2. Emotional distress
  3. Performance status decreased
  4. Pericardial disease
  5. Pericardial effusion (fluid around the heart)
  6. Pericarditis constrictive (inflammation of the pericardium-constrictive)
  7. Pleural effusion (water on the lungs)
  8. Psychological trauma
  9. Anxiety
  10. Hair colour changes

What are the existing conditions these people have? *

  1. Breast Cancer Female: 17 people, 68.00%
  2. Breast Cancer: 5 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and Ellence?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Synthroid and Ellence:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ellence:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Synthroid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ellence and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium and epirubicin hydrochloride (the active ingredients of Synthroid and Ellence, respectively), and Synthroid and Ellence (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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