Synthroid and Fazaclo odt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and Fazaclo odt (clozapine). Common drug interactions include agranulocytosis among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and Fazaclo odt. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,205 Synthroid users. Check the latest studies of Synthroid.

What is Fazaclo odt?

Fazaclo odt has active ingredients of clozapine. eHealthMe is studying from 728 Fazaclo odt users. Check the latest studies of Fazaclo odt.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

17 people who take Synthroid and Fazaclo odt together, and have interactions are studied.

Synthroid and Fazaclo odt drug interactions.

What are the common drug interactions of Synthroid and Fazaclo Odt, by gender? *:

female:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
General physical health deterioration (weak health status)
Leukopenia (less number of white blood cells in blood)
Sepsis (a severe blood infection that can lead to organ failure and death)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Breast cancer
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

male:

Cardiac arrest
Death
Respiratory disorder (respiratory disease)
Upper airway obstruction
Abnormal behaviour
Anaemia (lack of blood)
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the common drug interactions of Synthroid and Fazaclo Odt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abnormal behaviour
Anaemia (lack of blood)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Head banging (violently shaking the head in time with the music)

50-59:

Cardiac arrest
Death
Arthralgia (joint pain)
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory disorder (respiratory disease)
Sepsis (a severe blood infection that can lead to organ failure and death)
Upper airway obstruction

60+:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
General physical health deterioration (weak health status)
Obesity (having too much body fat)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sleep disorder
Leukopenia (less number of white blood cells in blood)
Arrhythmia (irregular heartbeat)
Breast cancer

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 29.41%
Psychotic Disorder: 3 people, 17.65%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 11.76%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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