Synthroid and Limbitrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and Limbitrol (amitriptyline hydrochloride; chlordiazepoxide). Common drug interactions include cataract among females and decreased interest among males.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and Limbitrol. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

What is Limbitrol?

Limbitrol has active ingredients of amitriptyline hydrochloride; chlordiazepoxide. It is often used in stress and anxiety. eHealthMe is studying from 378 Limbitrol users. Check the latest studies of Limbitrol.

On Jul, 27, 2026

19 people who take Synthroid and Limbitrol together, and have interactions are studied.

Synthroid and Limbitrol drug interactions.

What are the common drug interactions of Synthroid and Limbitrol, by gender? *:

female:

Cataract (clouding of the lens inside the eye)
Constipation
Decreased activity
Decreased appetite
Depression
Diarrhoea
Drug administration error
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysphagia (a condition in which swallowing is difficult or painful)

male:

Decreased interest
Diplopia (double vision)
Tremor (trembling or shaking movements in one or more parts of your body)
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)
Visual impairment
Abdominal distension
Acquired cardiac septal defect (hole in the heart)
Anaemia (lack of blood)
Apnoea (suspension of external breathing)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

What are the common drug interactions of Synthroid and Limbitrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Melaena (the passage of black, tarry stools)

30-39:

n/a

40-49:

Asthenia (weakness)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Fatigue (feeling of tiredness)
Hallucination, visual (seeing things that aren't there)
Hypotension (abnormally low blood pressure)

50-59:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysphagia (a condition in which swallowing is difficult or painful)
Emotional distress
Fall
Flat affect (absence of emotional response to a situation)
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)

60+:

Decreased interest
Diplopia (double vision)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Tremor (trembling or shaking movements in one or more parts of your body)
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)
Visual impairment
Abdominal distension
Abdominal pain

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 21.05%
High Blood Cholesterol: 2 people, 10.53%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.26%
Sleep Disorder: 1 person, 5.26%
Prothrombin Level Decreased: 1 person, 5.26%
Growth Hormone Deficiency: 1 person, 5.26%
Enlarged Prostate: 1 person, 5.26%
Breast Cancer: 1 person, 5.26%
Back Pain: 1 person, 5.26%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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